Long-term maintenance of human naïve T cells through in situ homeostasis in lymphoid tissue sites

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Science Immunology  02 Dec 2016:
Vol. 1, Issue 6, eaah6506
DOI: 10.1126/sciimmunol.aah6506

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T cell life doesn’t end at 40

Naïve T cells develop in the thymus. Although thymic function declines with age, T cells are persistent throughout the human life span. Thome et al. examined human lymphoid tissues from donors ranging from 2 months to 73 years in age. They found that, although the number of double-positive thymocytes and recent thymic emigrants dropped in individuals >40 years of age, naïve T cells were functionally maintained in the lymph nodes. There was minimal overlap in clonotype between the lymph tissues, suggesting that lymph nodes may maintain a diverse set of T cell specificities. These data suggest that location really does matter—tissue compartmentalization and homeostasis are critical for maintaining naïve T cells throughout the human life span.