Long-term maintenance of human naïve T cells through in situ homeostasis in lymphoid tissue sites

Joseph J. C. Thome; Boris Grinshpun; Brahma V. Kumar; Masaru Kubota; Yoshiaki Ohmura; Harvey Lerner; Gregory D. Sempowski; Yufeng Shen; Donna L. Farber

doi:10.1126/sciimmunol.aah6506

Research ArticleHUMAN IMMUNOLOGY

Long-term maintenance of human naïve T cells through in situ homeostasis in lymphoid tissue sites

Joseph J. C. Thome¹,²,*,
Boris Grinshpun³,*,
Brahma V. Kumar¹,
Masaru Kubota¹,⁴,
Yoshiaki Ohmura¹,⁴,
Harvey Lerner⁵,
Gregory D. Sempowski⁶,
Yufeng Shen³ and
Donna L. Farber¹,²,⁴,†

¹Columbia Center for Translational Immunology, Columbia University Medical Center, New York, NY 10032, USA.
²Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032, USA.
³Department of Systems Biology, Columbia University Medical Center, New York, NY 10032, USA.
⁴Department of Surgery, Columbia University Medical Center, New York, NY 10032, USA.
⁵LiveOnNY, New York, NY 10001, USA.
⁶Human Vaccine Institute, Duke University, Durham, NC 27710, USA.

↵†Corresponding author. Email: df2396{at}cumc.columbia.edu

↵* These authors contributed equally to this work.

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Science Immunology 02 Dec 2016:
Vol. 1, Issue 6, eaah6506
DOI: 10.1126/sciimmunol.aah6506

Joseph J. C. Thome

1Columbia Center for Translational Immunology, Columbia University Medical Center, New York, NY 10032, USA.

2Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032, USA.

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Boris Grinshpun

3Department of Systems Biology, Columbia University Medical Center, New York, NY 10032, USA.

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Brahma V. Kumar

1Columbia Center for Translational Immunology, Columbia University Medical Center, New York, NY 10032, USA.

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Masaru Kubota

1Columbia Center for Translational Immunology, Columbia University Medical Center, New York, NY 10032, USA.

4Department of Surgery, Columbia University Medical Center, New York, NY 10032, USA.

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Yoshiaki Ohmura

1Columbia Center for Translational Immunology, Columbia University Medical Center, New York, NY 10032, USA.

4Department of Surgery, Columbia University Medical Center, New York, NY 10032, USA.

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Harvey Lerner

5LiveOnNY, New York, NY 10001, USA.

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Gregory D. Sempowski

6Human Vaccine Institute, Duke University, Durham, NC 27710, USA.

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Yufeng Shen

3Department of Systems Biology, Columbia University Medical Center, New York, NY 10032, USA.

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Donna L. Farber

1Columbia Center for Translational Immunology, Columbia University Medical Center, New York, NY 10032, USA.

2Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032, USA.

4Department of Surgery, Columbia University Medical Center, New York, NY 10032, USA.

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For correspondence: df2396@cumc.columbia.edu

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Long-term maintenance of human naïve T cells through in situ homeostasis in lymphoid tissue sites

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