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Research ArticleHUMAN IMMUNOLOGY
Long-term maintenance of human naïve T cells through in situ homeostasis in lymphoid tissue sites
- Joseph J. C. Thome1,2,*,
- Boris Grinshpun3,*,
- Brahma V. Kumar1,
- Masaru Kubota1,4,
- Yoshiaki Ohmura1,4,
- Harvey Lerner5,
- Gregory D. Sempowski6,
- Yufeng Shen3 and
- Donna L. Farber1,2,4,†
- 1Columbia Center for Translational Immunology, Columbia University Medical Center, New York, NY 10032, USA.
- 2Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032, USA.
- 3Department of Systems Biology, Columbia University Medical Center, New York, NY 10032, USA.
- 4Department of Surgery, Columbia University Medical Center, New York, NY 10032, USA.
- 5LiveOnNY, New York, NY 10001, USA.
- 6Human Vaccine Institute, Duke University, Durham, NC 27710, USA.
- ↵†Corresponding author. Email: df2396{at}cumc.columbia.edu
↵* These authors contributed equally to this work.
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Science Immunology 02 Dec 2016:
Vol. 1, Issue 6, eaah6506
DOI: 10.1126/sciimmunol.aah6506
Vol. 1, Issue 6, eaah6506
DOI: 10.1126/sciimmunol.aah6506
Joseph J. C. Thome
1Columbia Center for Translational Immunology, Columbia University Medical Center, New York, NY 10032, USA.
2Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032, USA.
Boris Grinshpun
3Department of Systems Biology, Columbia University Medical Center, New York, NY 10032, USA.
Brahma V. Kumar
1Columbia Center for Translational Immunology, Columbia University Medical Center, New York, NY 10032, USA.
Masaru Kubota
1Columbia Center for Translational Immunology, Columbia University Medical Center, New York, NY 10032, USA.
4Department of Surgery, Columbia University Medical Center, New York, NY 10032, USA.
Yoshiaki Ohmura
1Columbia Center for Translational Immunology, Columbia University Medical Center, New York, NY 10032, USA.
4Department of Surgery, Columbia University Medical Center, New York, NY 10032, USA.
Harvey Lerner
5LiveOnNY, New York, NY 10001, USA.
Gregory D. Sempowski
6Human Vaccine Institute, Duke University, Durham, NC 27710, USA.
Yufeng Shen
3Department of Systems Biology, Columbia University Medical Center, New York, NY 10032, USA.
Donna L. Farber
1Columbia Center for Translational Immunology, Columbia University Medical Center, New York, NY 10032, USA.
2Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032, USA.
4Department of Surgery, Columbia University Medical Center, New York, NY 10032, USA.
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