Research ArticleDENDRITIC CELLS

Human lymphoid organ dendritic cell identity is predominantly dictated by ontogeny, not tissue microenvironment

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Science Immunology  16 Dec 2016:
Vol. 1, Issue 6, eaai7677
DOI: 10.1126/sciimmunol.aai7677

Article Information

vol. 1 no. 6

PubMed: 
Published By: 
History: 
  • Received August 9, 2016
  • Accepted November 14, 2016

Author Information

  1. Gordon F. Heidkamp1,*,
  2. Jil Sander2,*,
  3. Christian H. K. Lehmann1,
  4. Lukas Heger1,
  5. Nathalie Eissing1,
  6. Anna Baranska1,,
  7. Jennifer J. Lühr1,
  8. Alana Hoffmann1,
  9. Katharina C. Reimer1,
  10. Anja Lux3,
  11. Stephan Söder4,
  12. Arndt Hartmann4,
  13. Johannes Zenk5,
  14. Thomas Ulas2,
  15. Naomi McGovern6,
  16. Christoph Alexiou7,
  17. Bernd Spriewald8,
  18. Andreas Mackensen8,
  19. Gerold Schuler9,
  20. Burkhard Schauf10,
  21. Anja Forster10,
  22. Roland Repp11,
  23. Peter A. Fasching12,
  24. Ariawan Purbojo13,
  25. Robert Cesnjevar13,
  26. Evelyn Ullrich14,15,
  27. Florent Ginhoux6,
  28. Andreas Schlitzer2,6,16,
  29. Falk Nimmerjahn3,
  30. Joachim L. Schultze2,16,*, and
  31. Diana Dudziak1,*,
  1. 1Department of Dermatology, Laboratory of Dendritic Cell Biology, Friedrich-Alexander University Erlangen-Nürnberg (FAU), University Hospital Erlangen, Erlangen, Germany.
  2. 2LIMES (Life and Medical Sciences) Institute, Genomics and Immunoregulation, University of Bonn, Bonn, Germany.
  3. 3Department of Biology, Chair of Genetics, FAU, Erlangen, Germany.
  4. 4Department of Pathology, FAU, University Hospital Erlangen, Erlangen, Germany.
  5. 5Department of Otorhinolaryngology, Klinikum Augsburg Süd, Augsburg, Germany.
  6. 6Singapore Immunology Network, A*STAR (Agency for Science Technology and Research), Singapore, Singapore.
  7. 7Section for Experimental Oncology and Nanomedicine, Department of Otorhinolaryngology, Head and Neck Surgery, Else Kröner-Fresenius-Stiftung-Professorship, FAU, University Hospital Erlangen, Erlangen, Germany.
  8. 8Department of Medicine 5, Hematology and Oncology, FAU, University Hospital Erlangen, Erlangen, Germany.
  9. 9Department of Dermatology, FAU, University Hospital Erlangen, Erlangen, Germany.
  10. 10Department of Obstetrics and Gynecology, Sozialstiftung Bamberg, Bamberg, Germany.
  11. 11Medical Department 2, Städtisches Krankenhaus Kiel, Kiel, Germany.
  12. 12Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, FAU, University Hospital Erlangen, Erlangen, Germany.
  13. 13Department of Pediatric Cardiac Surgery, FAU, University Hospital Erlangen, Erlangen, Germany.
  14. 14LOEWE Center for Cell and Gene Therapy, Goethe University, Frankfurt, Germany.
  15. 15Division for Stem Cell Transplantation and Immunology, Department for Children and Adolescents Medicine, Hospital of the Goethe University, Frankfurt, Germany.
  16. 16Platform for Single Cell Genomics and Epigenomics (PRECISE) at the University of Bonn and the German Center for Neurodegenerative Diseases, Bonn, Germany.
  1. Corresponding author. Email: diana.dudziak{at}uk-erlangen.de (D.D.); j.schultze{at}uni-bonn.de (J.L.S.)
  1. * These authors contributed equally to this work.

  • Present address: Centre d’Immunologie de Marseille-Luminy, Aix Marseille Université, INSERM-CNRS, Marseille-Luminy, France.

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