Contents
April 2017
Vol 2, Issue 10
Vol 2, Issue 10
Focus
- Commensal bacteria (ab)use CD8+ T cells to induce insulin resistance
Type I interferon–dependent expansion of intrahepatic CD8+ T cells promotes systemic insulin resistance in obesity. See the related Research Article by Ghazarian et al.
Research Articles
- The lung is a host defense niche for immediate neutrophil-mediated vascular protection
Pulmonary capillaries provide a home for neutrophil surveillance to capture bloodstream bacteria.
- Complement factor P is a ligand for the natural killer cell–activating receptor NKp46
Cross-talk between innate lymphoid cells and the alternative complement pathway protects against invasive bacterial infections.
- Type I interferon responses drive intrahepatic T cells to promote metabolic syndrome
Obesity-related insulin resistance correlates with type I interferon–driven activation and expansion of intrahepatic T cells. See the related Focus by Ma et al.
- Synovial fibroblast-neutrophil interactions promote pathogenic adaptive immunity in rheumatoid arthritis
Neutrophil extracellular traps containing citrullinated peptides promote inflammation in synovial fibroblasts.
- Resident memory T cells in the skin mediate durable immunity to melanoma
Resident memory CD8 T cells maintained in vitiligo-affected skin mediate long-lived protection against melanoma.
- Eomesodermin promotes the development of type 1 regulatory T (TR1) cells
TR1 cells are the major regulatory population generated after allogeneic bone marrow transplantation.
- Distinct oxysterol requirements for positioning naïve and activated dendritic cells in the spleen
Two ligands modulate chemoattractant receptor EBI2-dependent positioning of splenic dendritic cells.
Editors' Choice
- Nurture trumps nature!
Mutation-associated infections in one individual are prevented in relatives with the same mutation by a compensatory adaptive immune response.
- Barrier busting yeast brew trouble in the gut
Saccharomyces cerevisiae, a common yeast in the gut, induces uric acid production by intestinal epithelium, leading to decreased barrier function and increased colitis in mouse models.
About The Cover
ONLINE COVER Promoting Tolerance. Depicted here is a type 1 regulatory T (TR1) cell (left) interacting with a dendritic cell (top right, dark purple) and an interleukin-27 (IL-27)–secreting macrophage (bottom right, light purple). Zhang et al. report that IL-27–driven commitment of T cells to the TR1 cell lineage limits graft-versus-host disease after bone marrow transplantation. [CREDIT: MADELEINE FLYNN, GRAPHIC SUPPORT OFFICER, QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE AND GARVIN GRULLÓN, AAAS]