Research ArticleMETABOLIC DISEASE

Type I interferon responses drive intrahepatic T cells to promote metabolic syndrome

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Science Immunology  21 Apr 2017:
Vol. 2, Issue 10, eaai7616
DOI: 10.1126/sciimmunol.aai7616

Article Information

vol. 2 no. 10

PubMed: 
Published By: 
History: 
  • Received August 8, 2016
  • Revision received February 8, 2017
  • Accepted March 27, 2017
  • .

Author Information

  1. Magar Ghazarian1,2,*,,
  2. Xavier S. Revelo1,*,,
  3. Mark K. Nøhr1,*,
  4. Helen Luck1,2,*,
  5. Kejing Zeng1,3,
  6. Helena Lei1,*,
  7. Sue Tsai1,*,
  8. Stephanie A. Schroer1,
  9. Yoo Jin Park1,
  10. Melissa Hui Yen Chng4,
  11. Lei Shen5,
  12. June Ann D’Angelo6,
  13. Peter Horton7,8,
  14. William C. Chapman9,
  15. Diane Brockmeier10,
  16. Minna Woo1,
  17. Edgar G. Engleman4,
  18. Oyedele Adeyi11,12,
  19. Naoto Hirano2,13,
  20. Tianru Jin1,
  21. Adam J. Gehring6,14,
  22. Shawn Winer1,12,15,,§ and
  23. Daniel A. Winer1,2,11,12,*,,§
  1. 1Division of Cellular and Molecular Biology, Diabetes Research Group, Toronto General Research Institute, University Health Network, 101 College Street, Toronto, Ontario M5G 1L7, Canada.
  2. 2Department of Immunology, University of Toronto, 1 King’s College Circle, Toronto, Ontario M5S 3B3, Canada.
  3. 3Department of Endocrinology and Metabolism, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.
  4. 4Department of Pathology, Stanford University School of Medicine, Palo Alto, CA 94205, USA.
  5. 5Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai 200240, China.
  6. 6Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, St. Louis, MO 63104, USA.
  7. 7Methodist University Hospital Transplant Institute, Memphis, TN 38104, USA.
  8. 8Division of Abdominal Transplant, Saint Louis University School of Medicine, St. Louis, MO 63104, USA.
  9. 9Division of Abdominal Transplant, Washington University School of Medicine, St. Louis, MO 63110, USA.
  10. 10Mid-America Transplant Services, St. Louis, MO 63110, USA.
  11. 11Department of Pathology, University Health Network, 200 Elizabeth Street, Toronto, Ontario M5G 2C4, Canada.
  12. 12Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
  13. 13Campbell Family Cancer Research Institute, University Health Network, Toronto, Ontario M5G 2M9, Canada.
  14. 14Toronto Centre for Liver Disease, University Health Network, Toronto, Ontario M5G 2C4, Canada.
  15. 15Department of Laboratory Medicine, St. Michael’s Hospital, Toronto, Ontario M5B 1W8, Canada.
  1. §Corresponding author. Email: shawn.winer{at}utoronto.ca (S.W.); dan.winer{at}uhn.ca (D.A.W.)
  1. These authors contributed equally to this work.

  • * Present address: 10-352 Toronto Medical Discovery Tower, Toronto, Ontario M5G 1L7, Canada.

  • Co-senior authors.

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