Research ArticleAUTOIMMUNITY
Suppression by human FOXP3+ regulatory T cells requires FOXP3-TIP60 interactions
- View ORCID ProfileKhalid Bin Dhuban1,2,*,
- View ORCID ProfileEva d’Hennezel1,*,†,
- View ORCID ProfileYasuhiro Nagai3,
- Yan Xiao3,
- View ORCID ProfileSteven Shao1,2,
- View ORCID ProfileRoman Istomine1,2,
- View ORCID ProfileFernando Alvarez1,2,
- Moshe Ben-Shoshan4,
- Hans Ochs5,
- Bruce Mazer4,6,
- Bin Li3,
- View ORCID ProfileChiyoko Sekine,
- Alan Berezov3,
- Wayne Hancock3,
- Troy R. Torgerson4,
- Mark I. Greene3 and
- View ORCID ProfileCiriaco A. Piccirillo1,2,6,8,‡
- 1Department of Microbiology and Immunology, McGill University and Research Institute of McGill University Health Centre, Montréal, Québec H3A 2B4, Canada.
- 2Program in Infectious Diseases and Immunology in Global Health, Centre for Translational Biology, Research Institute of McGill University Health Centre, Montréal, Québec H4A 3J1, Canada.
- 3Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104–6082, USA.
- 4Division of Pediatric Allergy and Clinical Immunology, Department of Pediatrics, McGill University Health Center, Montréal, Québec H3H 1P3, Canada.
- 5Department of Pediatrics, University of Washington School of Medicine, Seattle, WA 98101–1304, USA.
- 6FOCiS Centre of Excellence in Translational Immunology (CETI), Montréal, Québec H4A 3J1, Canada.
- 7Department of Clinical Research Medicine, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, Tokyo 173-8605, Japan.
- 8Division of Allergy and Clinical Immunology, Department of Medicine, McGill University and McGill University Health Centre, Montreal, Quebec, Canada.
- ↵‡Corresponding author. Email: ciro.piccirillo{at}mcgill.ca
↵* These authors contributed equally to this work.
↵† Present address: Novartis Institutes for Biomedical Research Inc., Cambridge, MA 02139, USA.
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Science Immunology 16 Jun 2017:
Vol. 2, Issue 12, eaai9297
DOI: 10.1126/sciimmunol.aai9297
Vol. 2, Issue 12, eaai9297
DOI: 10.1126/sciimmunol.aai9297
Khalid Bin Dhuban
1Department of Microbiology and Immunology, McGill University and Research Institute of McGill University Health Centre, Montréal, Québec H3A 2B4, Canada.
2Program in Infectious Diseases and Immunology in Global Health, Centre for Translational Biology, Research Institute of McGill University Health Centre, Montréal, Québec H4A 3J1, Canada.
Eva d’Hennezel
1Department of Microbiology and Immunology, McGill University and Research Institute of McGill University Health Centre, Montréal, Québec H3A 2B4, Canada.
Yasuhiro Nagai
3Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104–6082, USA.
Yan Xiao
3Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104–6082, USA.
Steven Shao
1Department of Microbiology and Immunology, McGill University and Research Institute of McGill University Health Centre, Montréal, Québec H3A 2B4, Canada.
2Program in Infectious Diseases and Immunology in Global Health, Centre for Translational Biology, Research Institute of McGill University Health Centre, Montréal, Québec H4A 3J1, Canada.
Roman Istomine
1Department of Microbiology and Immunology, McGill University and Research Institute of McGill University Health Centre, Montréal, Québec H3A 2B4, Canada.
2Program in Infectious Diseases and Immunology in Global Health, Centre for Translational Biology, Research Institute of McGill University Health Centre, Montréal, Québec H4A 3J1, Canada.
Fernando Alvarez
1Department of Microbiology and Immunology, McGill University and Research Institute of McGill University Health Centre, Montréal, Québec H3A 2B4, Canada.
2Program in Infectious Diseases and Immunology in Global Health, Centre for Translational Biology, Research Institute of McGill University Health Centre, Montréal, Québec H4A 3J1, Canada.
Moshe Ben-Shoshan
4Division of Pediatric Allergy and Clinical Immunology, Department of Pediatrics, McGill University Health Center, Montréal, Québec H3H 1P3, Canada.
Hans Ochs
5Department of Pediatrics, University of Washington School of Medicine, Seattle, WA 98101–1304, USA.
Bruce Mazer
4Division of Pediatric Allergy and Clinical Immunology, Department of Pediatrics, McGill University Health Center, Montréal, Québec H3H 1P3, Canada.
6FOCiS Centre of Excellence in Translational Immunology (CETI), Montréal, Québec H4A 3J1, Canada.
Bin Li
3Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104–6082, USA.
Chiyoko Sekine
Alan Berezov
3Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104–6082, USA.
Wayne Hancock
3Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104–6082, USA.
Troy R. Torgerson
4Division of Pediatric Allergy and Clinical Immunology, Department of Pediatrics, McGill University Health Center, Montréal, Québec H3H 1P3, Canada.
Mark I. Greene
3Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104–6082, USA.
Ciriaco A. Piccirillo
1Department of Microbiology and Immunology, McGill University and Research Institute of McGill University Health Centre, Montréal, Québec H3A 2B4, Canada.
2Program in Infectious Diseases and Immunology in Global Health, Centre for Translational Biology, Research Institute of McGill University Health Centre, Montréal, Québec H4A 3J1, Canada.
6FOCiS Centre of Excellence in Translational Immunology (CETI), Montréal, Québec H4A 3J1, Canada.
8Division of Allergy and Clinical Immunology, Department of Medicine, McGill University and McGill University Health Centre, Montreal, Quebec, Canada.
