Research ArticleTRANSPLANTATION

Donor SIRPα polymorphism modulates the innate immune response to allogeneic grafts

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Science Immunology  23 Jun 2017:
Vol. 2, Issue 12, eaam6202
DOI: 10.1126/sciimmunol.aam6202

Article Information

vol. 2 no. 12

PubMed: 
Published By: 
History: 
  • Received December 18, 2016
  • Accepted May 15, 2017
  • .

Author Information

  1. Hehua Dai1,
  2. Andrew J. Friday1,
  3. Khodor I. Abou-Daya1,
  4. Amanda L. Williams1,
  5. Steven Mortin-Toth2,
  6. Matthew L. Nicotra1,3,
  7. David M. Rothstein1,3,4,
  8. Warren D. Shlomchik1,3,4,
  9. Takashi Matozaki5,
  10. Jeffrey S. Isenberg6,
  11. Martin H. Oberbarnscheidt1,2,
  12. Jayne S. Danska2,7,*, and
  13. Fadi G. Lakkis1,3,4,*,
  1. 1Thomas E. Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.
  2. 2Program in Genetics and Genome Biology, Hospital for Sick Children Research Institute, Toronto, Ontario M5G1X8, Canada.
  3. 3Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.
  4. 4Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.
  5. 5Division of Molecular and Cellular Signaling, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Kobe 650-0017, Japan.
  6. 6Heart, Lung, Blood, and Vascular Medicine Institute and Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.
  7. 7Departments of Immunology and Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, Ontario M5S1A8, Canada.
  1. *Corresponding author. Email: jayne.danska{at}sickkids.ca (J.S.D.); lakkisf{at}upmc.edu (F.G.L.)
  1. These authors contributed equally to this work.

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