Plasmodium products persist in the bone marrow and promote chronic bone loss

Michelle S. J. Lee; Kenta Maruyama; Yukiko Fujita; Aki Konishi; Patrick M. Lelliott; Sawako Itagaki; Toshihiro Horii; Jing-wen Lin; Shahid M. Khan; Etsushi Kuroda; Shizuo Akira; Ken J. Ishii; Cevayir Coban

doi:10.1126/sciimmunol.aam8093

Research ArticleINFECTIOUS DISEASE

Plasmodium products persist in the bone marrow and promote chronic bone loss

View ORCID ProfileMichelle S. J. Lee¹,
Kenta Maruyama²,
Yukiko Fujita¹,
Aki Konishi¹,
View ORCID ProfilePatrick M. Lelliott¹,
Sawako Itagaki³,
View ORCID ProfileToshihiro Horii³,
View ORCID ProfileJing-wen Lin⁴,⁵,
View ORCID ProfileShahid M. Khan⁴,
View ORCID ProfileEtsushi Kuroda⁶,⁷,
Shizuo Akira²,
View ORCID ProfileKen J. Ishii⁶,⁷ and
View ORCID ProfileCevayir Coban¹,*

¹Laboratory of Malaria Immunology, Immunology Frontier Research Center (IFReC), Osaka University, 3-1 Yamadaoka, Suita, Osaka 565-0871, Japan.
²Laboratory of Host Defense, IFReC, Osaka University, Suita, Osaka 565-0871, Japan.
³Department of Molecular Protozoology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565-0871, Japan.
⁴Leiden Malaria Research Group, Department of Parasitology, Leiden University Medical Centre, 2333 ZA Leiden, Netherlands.
⁵Division of Pediatric Infectious Diseases, State Key Laboratory of Biotherapy, West China Second Hospital, Sichuan University and Collaboration Innovation Centre, Chengdu 610041, China.
⁶Laboratory of Vaccine Science, IFReC, Osaka University, Suita, Osaka 565-0871, Japan.
⁷Laboratory of Adjuvant Innovation, National Institutes of Biomedical Innovation, Health and Nutrition, 7-6-8 Saito-Asagi, Ibaraki, Osaka 567-0085, Japan.

↵*Corresponding author. Email: ccoban{at}biken.osaka-u.ac.jp

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Science Immunology 02 Jun 2017:
Vol. 2, Issue 12, eaam8093
DOI: 10.1126/sciimmunol.aam8093

Michelle S. J. Lee

1Laboratory of Malaria Immunology, Immunology Frontier Research Center (IFReC), Osaka University, 3-1 Yamadaoka, Suita, Osaka 565-0871, Japan.

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ORCID record for Michelle S. J. Lee

Kenta Maruyama

2Laboratory of Host Defense, IFReC, Osaka University, Suita, Osaka 565-0871, Japan.

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Yukiko Fujita

1Laboratory of Malaria Immunology, Immunology Frontier Research Center (IFReC), Osaka University, 3-1 Yamadaoka, Suita, Osaka 565-0871, Japan.

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Aki Konishi

1Laboratory of Malaria Immunology, Immunology Frontier Research Center (IFReC), Osaka University, 3-1 Yamadaoka, Suita, Osaka 565-0871, Japan.

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Patrick M. Lelliott

1Laboratory of Malaria Immunology, Immunology Frontier Research Center (IFReC), Osaka University, 3-1 Yamadaoka, Suita, Osaka 565-0871, Japan.

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Sawako Itagaki

3Department of Molecular Protozoology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565-0871, Japan.

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Toshihiro Horii

3Department of Molecular Protozoology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565-0871, Japan.

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Jing-wen Lin

4Leiden Malaria Research Group, Department of Parasitology, Leiden University Medical Centre, 2333 ZA Leiden, Netherlands.

5Division of Pediatric Infectious Diseases, State Key Laboratory of Biotherapy, West China Second Hospital, Sichuan University and Collaboration Innovation Centre, Chengdu 610041, China.

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Shahid M. Khan

4Leiden Malaria Research Group, Department of Parasitology, Leiden University Medical Centre, 2333 ZA Leiden, Netherlands.

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Etsushi Kuroda

6Laboratory of Vaccine Science, IFReC, Osaka University, Suita, Osaka 565-0871, Japan.

7Laboratory of Adjuvant Innovation, National Institutes of Biomedical Innovation, Health and Nutrition, 7-6-8 Saito-Asagi, Ibaraki, Osaka 567-0085, Japan.

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Shizuo Akira

2Laboratory of Host Defense, IFReC, Osaka University, Suita, Osaka 565-0871, Japan.

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Ken J. Ishii

6Laboratory of Vaccine Science, IFReC, Osaka University, Suita, Osaka 565-0871, Japan.

7Laboratory of Adjuvant Innovation, National Institutes of Biomedical Innovation, Health and Nutrition, 7-6-8 Saito-Asagi, Ibaraki, Osaka 567-0085, Japan.

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Cevayir Coban

1Laboratory of Malaria Immunology, Immunology Frontier Research Center (IFReC), Osaka University, 3-1 Yamadaoka, Suita, Osaka 565-0871, Japan.

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For correspondence: ccoban@biken.osaka-u.ac.jp

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