Memory-phenotype CD4+ T cells spontaneously generated under steady-state conditions exert innate TH1-like effector function

Takeshi Kawabe; Dragana Jankovic; Shuko Kawabe; Yuefeng Huang; Ping-Hsien Lee; Hidehiro Yamane; Jinfang Zhu; Alan Sher; Ronald N. Germain; William E. Paul

doi:10.1126/sciimmunol.aam9304

Research ArticleINFECTIOUS DISEASE

Memory-phenotype CD4⁺ T cells spontaneously generated under steady-state conditions exert innate T_H1-like effector function

View ORCID ProfileTakeshi Kawabe¹,²,*,
Dragana Jankovic²,
Shuko Kawabe¹,
Yuefeng Huang¹,
View ORCID ProfilePing-Hsien Lee¹,
Hidehiro Yamane¹,
Jinfang Zhu³,
View ORCID ProfileAlan Sher²,*,
View ORCID ProfileRonald N. Germain¹,⁴,* and
William E. Paul¹,†

¹Cytokine Biology Unit, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
²Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
³Molecular and Cellular Immunoregulation Unit, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
⁴Lymphocyte Biology Section, Laboratory of Systems Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

↵*Corresponding author. Email: takeshi.kawabe{at}nih.gov (T.K.); asher{at}niaid.nih.gov (A.S.); rgermain{at}niaid.nih.gov (R.N.G.)

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Science Immunology 16 Jun 2017:
Vol. 2, Issue 12, eaam9304
DOI: 10.1126/sciimmunol.aam9304

Takeshi Kawabe

1Cytokine Biology Unit, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

2Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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ORCID record for Takeshi Kawabe
For correspondence: takeshi.kawabe@nih.gov asher@niaid.nih.gov rgermain@niaid.nih.gov

Dragana Jankovic

2Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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Shuko Kawabe

1Cytokine Biology Unit, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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Yuefeng Huang

1Cytokine Biology Unit, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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Ping-Hsien Lee

1Cytokine Biology Unit, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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ORCID record for Ping-Hsien Lee

Hidehiro Yamane

1Cytokine Biology Unit, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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Jinfang Zhu

3Molecular and Cellular Immunoregulation Unit, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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Alan Sher

2Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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ORCID record for Alan Sher
For correspondence: takeshi.kawabe@nih.gov asher@niaid.nih.gov rgermain@niaid.nih.gov

Ronald N. Germain

1Cytokine Biology Unit, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

4Lymphocyte Biology Section, Laboratory of Systems Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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ORCID record for Ronald N. Germain
For correspondence: takeshi.kawabe@nih.gov asher@niaid.nih.gov rgermain@niaid.nih.gov

William E. Paul

1Cytokine Biology Unit, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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Memory-phenotype CD4⁺ T cells spontaneously generated under steady-state conditions exert innate T_H1-like effector function

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