Structural basis for potent antibody-mediated neutralization of human cytomegalovirus

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Science Immunology  30 Jun 2017:
Vol. 2, Issue 12, eaan1457
DOI: 10.1126/sciimmunol.aan1457

Function follows form

Congenital human cytomegalovirus (HCMV) is the most common infectious cause of disabilities in newborn infants and the leading cause of deafness in children, highlighting the need for a vaccine that induces neutralizing antibodies to block maternal-fetal transmission of HCMV. Now, Chandramouli et al. report crystal structures of neutralizing antibodies bound to the HCMV pentameric complex (Pentamer), a key determinant of viral entry. These structural and functional studies identify potential entry receptor–binding sites on Pentamer as well as other functional sites that may serve as targets for vaccine development and antibody and small-molecule therapeutics.

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