Contents
July 2017
Vol 2, Issue 13
Vol 2, Issue 13
Focus
- RAB15 empowers dendritic cells to drive antiviral immunity
CD1c+ and CD141+ dendritic cells cooperate to sustain antiviral T cell responses. See the related research article by Silvin et al.
Research Articles
- Tumor-derived exosomes modulate PD-L1 expression in monocytes
Transfer of exosomal RNA from leukemic cells to monocytes induces immunosuppression.
- Helicobacter species are potent drivers of colonic T cell responses in homeostasis and inflammation
Helicobacter in the intestine induce regulatory T cells during homeostasis and effector T cells during colonic inflammation.
- Dendritic cell–targeted lentiviral vector immunization uses pseudotransduction and DNA-mediated STING and cGAS activation
Lentiviral vector preparations stimulate immune responses via the host STING and cGAS pathway and pseudotransduction.
- Preferential induction of cross-group influenza A hemagglutinin stem–specific memory B cells after H7N9 immunization in humans
Broadly protective antibodies are preferentially induced upon vaccination with a group 2 immunogen.
- Constitutive resistance to viral infection in human CD141+ dendritic cells
Specialized human dendritic cells that resist viral infection activate T cells by relying on bystander cells for antigen production. See the related Focus by Wong et al.
Editors' Choice
- Type I interference with self-tolerance
Common variant of the RNA sensor IFIH1 enhances antiviral responses but also increases the risk of autoimmune disease.
- Turning Charon around on the Styx?
Sestrins drive immune senescence, and their inhibition may restore immunity in the elderly and improve vaccine responses.
About The Cover
ONLINE COVER Teaming Up to Defend. Depicted here are CD141+ dendritic cells (DCs, green), which resist infection by enveloped viruses (yellow spheres), and CD1c+ DCs (orange), which are susceptible to infection. Silvin et al. report that CD141+ DCs acquire viral antigen from infected CD1c+ DCs and prime antiviral T cell responses. [CREDIT: RENAUD CHABRIER, WWW.RENAUDCHABRIR.COM]