Research ArticleCANCER

Tumor-derived exosomes modulate PD-L1 expression in monocytes

See allHide authors and affiliations

Science Immunology  28 Jul 2017:
Vol. 2, Issue 13, eaah5509
DOI: 10.1126/sciimmunol.aah5509

Messaging with RNAs

Understanding interactions between tumor cells and immune cells is essential for tailoring immunocentric therapies to tumors. Here, Haderk et al. have identified a key role for tumor-derived exosomes in modulating immune responses to chronic lymphocytic leukemia (CLL). They report that CLL-derived exosomal RNAs promote monocytes in CLL patients to adopt an immunosuppressive phenotype, including promoting expression of PD-L1. They identify noncoding RNA hY4 as a key functional component of CLL-derived exosomes and show that hY4 promotes exosome-dependent skewing of monocytes in a TLR7-dependent manner. Using mouse models, they found that inhibition of TLR7 delayed progression of CLL, opening up the possibility that the TLR7 pathway could be therapeutically targeted in CLL.

View Full Text

Stay Connected to Science Immunology