Contents
September 2017
Vol 2, Issue 15
Vol 2, Issue 15
Focus
- What to expect when you’re expecting
In this issue, Aghaeepour et al. apply systems immunology to study human pregnancy.
Research Articles
- Dynamics of the human antibody repertoire after B cell depletion in systemic sclerosis
Immune repertoire sequencing reveals humoral signatures of systemic sclerosis and uncovers determinism in the repertoire’s response to B cell depletion.
- Skin infections are eliminated by cooperation of the fibrinolytic and innate immune systems
A balanced TGF-β–mediated fibrotic response drives the control and elimination of fungal and bacterial skin infections.
- KIR2DS2 recognizes conserved peptides derived from viral helicases in the context of HLA-C
KIR2DS2, an activating natural killer cell receptor, recognizes conserved peptides derived from the RNA helicases of pathogenic flaviviruses.
- Tfr cells lack IL-2Rα but express decoy IL-1R2 and IL-1Ra and suppress the IL-1–dependent activation of Tfh cells
Follicular regulatory T cells suppress B cell activation by expression of decoy IL-1R2 and IL-1Ra.
- An immune clock of human pregnancy
High-dimensional analysis reveals the chronology of immunological adaptations during the course of human pregnancies.
Editors' Choice
- A recycling program that keeps PD-L1 out of the cancer cell's junkyard
CMTM6 limits antitumor immunity by ensuring efficient recycling of endocytosed PD-L1 protein.
- A role for T helper cells in anti–CTLA-4 therapy
Comparison of immune responses to CTLA4 and PD-1 blockade uncovers a role for helper T cells in anti–CTLA-4 therapy.
About The Cover
ONLINE COVER On the Clock. During pregnancy, the mother's organ systems, including her immune system, adapt to the growing fetus. By carrying out high-dimensional analyses of immune responses in pregnant women, Aghaeepour et al. have charted immune system adaptations during the course of a human pregnancy. This immunological time line is critical for healthy mothers and babies. [CREDIT: JONYA/ISTOCKPHOTO]
