Contents
October 2017
Vol 2, Issue 16
Vol 2, Issue 16
Research Articles
- Lysosome signaling controls the migration of dendritic cells
Lysosomes control dendritic cell migration by linking macropinocytosis to cytoskeletal rearrangement via the TFEB-TRPML1 axis.
- A molecular basis of human T cell receptor autoreactivity toward self-phospholipids
Structure of autoreactive CD1b-restricted T cell receptor (TCR) provides insights into lipid autoreactivity of TCRs.
- Interleukin-10 from CD4+ follicular regulatory T cells promotes the germinal center response
Follicular regulatory T cells promote the germinal center response after viral infection through provision of IL-10.
- Enzymatic synthesis of core 2 O-glycans governs the tissue-trafficking potential of memory CD8+ T cells
Central memory CD8+ T cells are the major memory CD8+ T cell subset that traffics into inflamed, nonlymphoid tissues.
- CD169+ macrophages orchestrate innate immune responses by regulating bacterial localization in the spleen
CD169+ macrophages in the spleen play an essential role in the clearance of Listeria monocytogenes.
- Type III interferon is a critical regulator of innate antifungal immunity
Type III interferons activate neutrophils to promote antifungal immune responses to Aspergillus fumigatus.
Editors' Choice
- JAKing up resistance to immunotherapy
A two-cell type CRISPR screen has identified genes and pathways that mediate resistance to cancer immunotherapy.
About The Cover
ONLINE COVER Lining Up to Defend. An image of a spleen from a mouse infected with Listeria monocytogenes was stained for CD169+ marginal zone macrophages (red), L. monocytogenes (green), and B cells (blue). Perez et al. show that strategically positioned marginal zone macrophages drive immune responses to L. monocytogenes by controlling pathogen localization in the spleen. [CREDIT: PEREZ ET AL./SCIENCE IMMUNOLOGY]