Lysosome signaling controls the migration of dendritic cells

Marine Bretou; Pablo J. Sáez; Doriane Sanséau; Mathieu Maurin; Danielle Lankar; Melanie Chabaud; Carmine Spampanato; Odile Malbec; Lucie Barbier; Shmuel Muallem; Paolo Maiuri; Andrea Ballabio; Julie Helft; Matthieu Piel; Pablo Vargas; Ana-Maria Lennon-Duménil

doi:10.1126/sciimmunol.aak9573

Research ArticleDENDRITIC CELLS

Lysosome signaling controls the migration of dendritic cells

View ORCID ProfileMarine Bretou¹,*,
View ORCID ProfilePablo J. Sáez¹,²,³,†,
View ORCID ProfileDoriane Sanséau¹,†,
View ORCID ProfileMathieu Maurin¹,†,
Danielle Lankar¹,
Melanie Chabaud¹,
Carmine Spampanato⁴,
View ORCID ProfileOdile Malbec¹,
View ORCID ProfileLucie Barbier²,³,⁵,
Shmuel Muallem⁶,
View ORCID ProfilePaolo Maiuri²,³,⁷,⁸,
View ORCID ProfileAndrea Ballabio⁴,⁹,¹⁰,
View ORCID ProfileJulie Helft¹,
View ORCID ProfileMatthieu Piel²,³,
View ORCID ProfilePablo Vargas¹,²,³,*,‡ and
View ORCID ProfileAna-Maria Lennon-Duménil¹,*,‡

¹INSERM U932 Immunité et Cancer, Institut Curie, Paris Sciences & Lettres Research University, F-75248 Paris, Cedex 05, France.
²Institut Curie, Paris Sciences & Lettres Research University, CNRS, UMR 144, F-75005 Paris, France.
³Institut Pierre-Gilles de Gennes, Paris Sciences & Lettres Research University, F-75005 Paris, France.
⁴Telethon Institute of Genetics and Medicine (TIGEM), I-80078 Pozzuoli, Naples, Italy.
⁵Université Paris-Sud, Université Paris-Saclay, F-91405 Orsay, France.
⁶Epithelial Signaling and Transport Section, Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.
⁷Institute FIRC (Italian Foundation for Cancer Research) of Molecular Oncology (IFOM-FIRC), I-20139 Milano, Italy.
⁸Istituto di Genetica Molecolare–Consiglio Nazionale delle Ricerche (IGM-CNR), Via Abbiategrasso 207, I-27100 Pavia, Italy.
⁹Medical Genetics, Department of Translational Medicine, Federico II University, I-80131 Naples, Italy.
¹⁰Department of Molecular and Human Genetics, Baylor College of Medicine and Jan and Dan Duncan Neurological Research Institute, Texas Children’s Hospital, Houston, TX 77030, USA.

↵*Corresponding author. Email: marine.bretou{at}curie.fr (M.B.); pablo.vargas{at}curie.fr (P.V.); amlennon{at}curie.fr (A.-M.L.-D.)

↵† These authors contributed equally to this work.
↵‡ These authors contributed equally to this work.

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Science Immunology 27 Oct 2017:
Vol. 2, Issue 16, eaak9573
DOI: 10.1126/sciimmunol.aak9573

Marine Bretou

1INSERM U932 Immunité et Cancer, Institut Curie, Paris Sciences & Lettres Research University, F-75248 Paris, Cedex 05, France.

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ORCID record for Marine Bretou
For correspondence: marine.bretou@curie.fr pablo.vargas@curie.fr amlennon@curie.fr

Pablo J. Sáez

1INSERM U932 Immunité et Cancer, Institut Curie, Paris Sciences & Lettres Research University, F-75248 Paris, Cedex 05, France.

2Institut Curie, Paris Sciences & Lettres Research University, CNRS, UMR 144, F-75005 Paris, France.

3Institut Pierre-Gilles de Gennes, Paris Sciences & Lettres Research University, F-75005 Paris, France.

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Doriane Sanséau

1INSERM U932 Immunité et Cancer, Institut Curie, Paris Sciences & Lettres Research University, F-75248 Paris, Cedex 05, France.

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Mathieu Maurin

1INSERM U932 Immunité et Cancer, Institut Curie, Paris Sciences & Lettres Research University, F-75248 Paris, Cedex 05, France.

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Danielle Lankar

1INSERM U932 Immunité et Cancer, Institut Curie, Paris Sciences & Lettres Research University, F-75248 Paris, Cedex 05, France.

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Melanie Chabaud

1INSERM U932 Immunité et Cancer, Institut Curie, Paris Sciences & Lettres Research University, F-75248 Paris, Cedex 05, France.

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Carmine Spampanato

4Telethon Institute of Genetics and Medicine (TIGEM), I-80078 Pozzuoli, Naples, Italy.

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Odile Malbec

1INSERM U932 Immunité et Cancer, Institut Curie, Paris Sciences & Lettres Research University, F-75248 Paris, Cedex 05, France.

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ORCID record for Odile Malbec

Lucie Barbier

2Institut Curie, Paris Sciences & Lettres Research University, CNRS, UMR 144, F-75005 Paris, France.

3Institut Pierre-Gilles de Gennes, Paris Sciences & Lettres Research University, F-75005 Paris, France.

5Université Paris-Sud, Université Paris-Saclay, F-91405 Orsay, France.

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Shmuel Muallem

6Epithelial Signaling and Transport Section, Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.

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Paolo Maiuri

2Institut Curie, Paris Sciences & Lettres Research University, CNRS, UMR 144, F-75005 Paris, France.

3Institut Pierre-Gilles de Gennes, Paris Sciences & Lettres Research University, F-75005 Paris, France.

7Institute FIRC (Italian Foundation for Cancer Research) of Molecular Oncology (IFOM-FIRC), I-20139 Milano, Italy.

8Istituto di Genetica Molecolare–Consiglio Nazionale delle Ricerche (IGM-CNR), Via Abbiategrasso 207, I-27100 Pavia, Italy.

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Andrea Ballabio

4Telethon Institute of Genetics and Medicine (TIGEM), I-80078 Pozzuoli, Naples, Italy.

9Medical Genetics, Department of Translational Medicine, Federico II University, I-80131 Naples, Italy.

10Department of Molecular and Human Genetics, Baylor College of Medicine and Jan and Dan Duncan Neurological Research Institute, Texas Children’s Hospital, Houston, TX 77030, USA.

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Julie Helft

1INSERM U932 Immunité et Cancer, Institut Curie, Paris Sciences & Lettres Research University, F-75248 Paris, Cedex 05, France.

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Matthieu Piel

2Institut Curie, Paris Sciences & Lettres Research University, CNRS, UMR 144, F-75005 Paris, France.

3Institut Pierre-Gilles de Gennes, Paris Sciences & Lettres Research University, F-75005 Paris, France.

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Pablo Vargas

1INSERM U932 Immunité et Cancer, Institut Curie, Paris Sciences & Lettres Research University, F-75248 Paris, Cedex 05, France.

2Institut Curie, Paris Sciences & Lettres Research University, CNRS, UMR 144, F-75005 Paris, France.

3Institut Pierre-Gilles de Gennes, Paris Sciences & Lettres Research University, F-75005 Paris, France.

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ORCID record for Pablo Vargas
For correspondence: marine.bretou@curie.fr pablo.vargas@curie.fr amlennon@curie.fr

Ana-Maria Lennon-Duménil

1INSERM U932 Immunité et Cancer, Institut Curie, Paris Sciences & Lettres Research University, F-75248 Paris, Cedex 05, France.

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ORCID record for Ana-Maria Lennon-Duménil
For correspondence: marine.bretou@curie.fr pablo.vargas@curie.fr amlennon@curie.fr

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Lysosome signaling controls the migration of dendritic cells

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