Lysosome signaling controls the migration of dendritic cells

Marine Bretou; Pablo J. Sáez; Doriane Sanséau; Mathieu Maurin; Danielle Lankar; Melanie Chabaud; Carmine Spampanato; Odile Malbec; Lucie Barbier; Shmuel Muallem; Paolo Maiuri; Andrea Ballabio; Julie Helft; Matthieu Piel; Pablo Vargas; Ana-Maria Lennon-Duménil

doi:10.1126/sciimmunol.aak9573

Research ArticleDENDRITIC CELLS

Lysosome signaling controls the migration of dendritic cells

Marine Bretou¹,*,
Pablo J. Sáez¹,²,³,†,
Doriane Sanséau¹,†,
Mathieu Maurin¹,†,
Danielle Lankar¹,
Melanie Chabaud¹,
Carmine Spampanato⁴,
Odile Malbec¹,
Lucie Barbier²,³,⁵,
Shmuel Muallem⁶,
Paolo Maiuri²,³,⁷,⁸,
Andrea Ballabio⁴,⁹,¹⁰,
Julie Helft¹,
Matthieu Piel²,³,
Pablo Vargas¹,²,³,*,‡ and
Ana-Maria Lennon-Duménil¹,*,‡

¹INSERM U932 Immunité et Cancer, Institut Curie, Paris Sciences & Lettres Research University, F-75248 Paris, Cedex 05, France.
²Institut Curie, Paris Sciences & Lettres Research University, CNRS, UMR 144, F-75005 Paris, France.
³Institut Pierre-Gilles de Gennes, Paris Sciences & Lettres Research University, F-75005 Paris, France.
⁴Telethon Institute of Genetics and Medicine (TIGEM), I-80078 Pozzuoli, Naples, Italy.
⁵Université Paris-Sud, Université Paris-Saclay, F-91405 Orsay, France.
⁶Epithelial Signaling and Transport Section, Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.
⁷Institute FIRC (Italian Foundation for Cancer Research) of Molecular Oncology (IFOM-FIRC), I-20139 Milano, Italy.
⁸Istituto di Genetica Molecolare–Consiglio Nazionale delle Ricerche (IGM-CNR), Via Abbiategrasso 207, I-27100 Pavia, Italy.
⁹Medical Genetics, Department of Translational Medicine, Federico II University, I-80131 Naples, Italy.
¹⁰Department of Molecular and Human Genetics, Baylor College of Medicine and Jan and Dan Duncan Neurological Research Institute, Texas Children’s Hospital, Houston, TX 77030, USA.

↵*Corresponding author. Email: marine.bretou{at}curie.fr (M.B.); pablo.vargas{at}curie.fr (P.V.); amlennon{at}curie.fr (A.-M.L.-D.)

↵† These authors contributed equally to this work.
↵‡ These authors contributed equally to this work.

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Science Immunology 27 Oct 2017:
Vol. 2, Issue 16, eaak9573
DOI: 10.1126/sciimmunol.aak9573

Marine Bretou

INSERM U932 Immunité et Cancer, Institut Curie, Paris Sciences & Lettres Research University, F-75248 Paris, Cedex 05, France.

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ORCID record for Marine Bretou
For correspondence: marine.bretou@curie.fr pablo.vargas@curie.fr amlennon@curie.fr

Pablo J. Sáez

INSERM U932 Immunité et Cancer, Institut Curie, Paris Sciences & Lettres Research University, F-75248 Paris, Cedex 05, France.Institut Curie, Paris Sciences & Lettres Research University, CNRS, UMR 144, F-75005 Paris, France.Institut Pierre-Gilles de Gennes, Paris Sciences & Lettres Research University, F-75005 Paris, France.

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Doriane Sanséau

INSERM U932 Immunité et Cancer, Institut Curie, Paris Sciences & Lettres Research University, F-75248 Paris, Cedex 05, France.

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Mathieu Maurin

INSERM U932 Immunité et Cancer, Institut Curie, Paris Sciences & Lettres Research University, F-75248 Paris, Cedex 05, France.

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Danielle Lankar

INSERM U932 Immunité et Cancer, Institut Curie, Paris Sciences & Lettres Research University, F-75248 Paris, Cedex 05, France.

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Melanie Chabaud

INSERM U932 Immunité et Cancer, Institut Curie, Paris Sciences & Lettres Research University, F-75248 Paris, Cedex 05, France.

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Carmine Spampanato

Telethon Institute of Genetics and Medicine (TIGEM), I-80078 Pozzuoli, Naples, Italy.

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Odile Malbec

INSERM U932 Immunité et Cancer, Institut Curie, Paris Sciences & Lettres Research University, F-75248 Paris, Cedex 05, France.

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Lucie Barbier

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Shmuel Muallem

Epithelial Signaling and Transport Section, Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.

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Paolo Maiuri

Institut Curie, Paris Sciences & Lettres Research University, CNRS, UMR 144, F-75005 Paris, France.Institut Pierre-Gilles de Gennes, Paris Sciences & Lettres Research University, F-75005 Paris, France.Institute FIRC (Italian Foundation for Cancer Research) of Molecular Oncology (IFOM-FIRC), I-20139 Milano, Italy.Istituto di Genetica Molecolare–Consiglio Nazionale delle Ricerche (IGM-CNR), Via Abbiategrasso 207, I-27100 Pavia, Italy.

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Andrea Ballabio

Telethon Institute of Genetics and Medicine (TIGEM), I-80078 Pozzuoli, Naples, Italy.Medical Genetics, Department of Translational Medicine, Federico II University, I-80131 Naples, Italy.Department of Molecular and Human Genetics, Baylor College of Medicine and Jan and Dan Duncan Neurological Research Institute, Texas Children’s Hospital, Houston, TX 77030, USA.

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Julie Helft

INSERM U932 Immunité et Cancer, Institut Curie, Paris Sciences & Lettres Research University, F-75248 Paris, Cedex 05, France.

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Matthieu Piel

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Pablo Vargas

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For correspondence: marine.bretou@curie.fr pablo.vargas@curie.fr amlennon@curie.fr

Ana-Maria Lennon-Duménil

INSERM U932 Immunité et Cancer, Institut Curie, Paris Sciences & Lettres Research University, F-75248 Paris, Cedex 05, France.

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ORCID record for Ana-Maria Lennon-Duménil
For correspondence: marine.bretou@curie.fr pablo.vargas@curie.fr amlennon@curie.fr

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Lysosome signaling controls the migration of dendritic cells

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