Research ArticleAUTOREACTIVITY
A molecular basis of human T cell receptor autoreactivity toward self-phospholipids
- View ORCID ProfileAdam Shahine1,2,
- View ORCID ProfileIldiko Van Rhijn3,4,
- View ORCID ProfileTan-Yun Cheng3,
- Sarah Iwany3,
- View ORCID ProfileStephanie Gras1,2,*,
- View ORCID ProfileD. Branch Moody3,* and
- View ORCID ProfileJamie Rossjohn1,2,5,*
- 1Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Australia.
- 2Australian Research Council Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, Victoria 3800, Australia.
- 3Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA.
- 4Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, 3584CL Utrecht, Netherlands.
- 5Institute of Infection and Immunity, Cardiff University School of Medicine, Heath Park, Cardiff CF14 4XN, UK.
- ↵*Corresponding author. Email: stephanie.gras{at}monash.edu (S.G.); bmoody{at}partners.org (D.B.M.); jamie.rossjohn{at}monash.edu (J.R.)
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Science Immunology 20 Oct 2017:
Vol. 2, Issue 16, eaao1384
DOI: 10.1126/sciimmunol.aao1384
Vol. 2, Issue 16, eaao1384
DOI: 10.1126/sciimmunol.aao1384
Adam Shahine
1Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Australia.
2Australian Research Council Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, Victoria 3800, Australia.
Ildiko Van Rhijn
3Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA.
4Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, 3584CL Utrecht, Netherlands.
Tan-Yun Cheng
3Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA.
Sarah Iwany
3Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA.
Stephanie Gras
1Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Australia.
2Australian Research Council Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, Victoria 3800, Australia.
D. Branch Moody
3Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA.
Jamie Rossjohn
1Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Australia.
2Australian Research Council Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, Victoria 3800, Australia.
5Institute of Infection and Immunity, Cardiff University School of Medicine, Heath Park, Cardiff CF14 4XN, UK.
