Research ArticleAUTOREACTIVITY
A molecular basis of human T cell receptor autoreactivity toward self-phospholipids
- Adam Shahine1,2,
- Ildiko Van Rhijn3,4,
- Tan-Yun Cheng3,
- Sarah Iwany3,
- Stephanie Gras1,2,*,
- D. Branch Moody3,* and
- Jamie Rossjohn1,2,5,*
- 1Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Australia.
- 2Australian Research Council Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, Victoria 3800, Australia.
- 3Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA.
- 4Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, 3584CL Utrecht, Netherlands.
- 5Institute of Infection and Immunity, Cardiff University School of Medicine, Heath Park, Cardiff CF14 4XN, UK.
- ↵*Corresponding author. Email: stephanie.gras{at}monash.edu (S.G.); bmoody{at}partners.org (D.B.M.); jamie.rossjohn{at}monash.edu (J.R.)
See allHide authors and affiliations
Science Immunology 20 Oct 2017:
Vol. 2, Issue 16, eaao1384
DOI: 10.1126/sciimmunol.aao1384
Vol. 2, Issue 16, eaao1384
DOI: 10.1126/sciimmunol.aao1384
Adam Shahine
Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Australia.Australian Research Council Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, Victoria 3800, Australia.
Ildiko Van Rhijn
Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA.Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, 3584CL Utrecht, Netherlands.
Tan-Yun Cheng
Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA.
Sarah Iwany
Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA.
Stephanie Gras
Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Australia.Australian Research Council Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, Victoria 3800, Australia.
D. Branch Moody
Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA.
Jamie Rossjohn
Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Australia.Australian Research Council Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, Victoria 3800, Australia.Institute of Infection and Immunity, Cardiff University School of Medicine, Heath Park, Cardiff CF14 4XN, UK.
