A PIP2-derived amplification loop fuels the sustained initiation of B cell activation

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Science Immunology  17 Nov 2017:
Vol. 2, Issue 17, eaan0787
DOI: 10.1126/sciimmunol.aan0787

Sustaining B cell receptor signaling

It is well established that, upon activation, B cell receptors (BCRs) form microclusters that function as platforms to recruit intracellular molecules that relay signals downstream of the BCRs. Xu et al. have examined how the localization of phosphatidylinositol 4,5-biphosphate (PIP2) is regulated to sustain BCR signaling. Using state-of-the-art microscopy to examine the localization of PIP2 after BCR activation, the authors report that PIP2 is depleted within the BCR microclusters but is enriched outside the microclusters. Furthermore, by developing systems to manipulate PIP2 localization in this context, the authors found that maintenance of this PIP2 gradient is vital to sustain BCR signaling.

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