Contents
December 2017
Vol 2, Issue 18
Vol 2, Issue 18
Focus
- GAPs in early life facilitate immune tolerance
Goblet cells deliver microbial antigens to generate regulatory T cells before and during weaning to induce long-term tolerance to symbionts. See the related research article by Knoop et al.
- Late arising T follicular helper cells cultivate the B cell crop during chronic infections
Follicular helper CD4+ T cells are essential for the development of neutralizing antibodies that contain chronic viral infection. See the related research article by Greczmiel et al.
Research Articles
- CD1a presentation of endogenous antigens by group 2 innate lymphoid cells
Human skin–derived ILC2 express CD1a and present endogenous PLA2G4A-dependent antigens to T cells.
- Microbial antigen encounter during a preweaning interval is critical for tolerance to gut bacteria
Bacterial antigen encounter in a preweaning interval is critical for developing antigen-specific tolerance to gut bacteria.
- GPR55 regulates intraepithelial lymphocyte migration dynamics and susceptibility to intestinal damage
GPR55 regulates intraepithelial lymphocyte interaction with the epithelium and restrains cell homing to the small intestine.
- Core-binding factor β and Runx transcription factors promote adaptive natural killer cell responses
Runx1 and Runx3 play nonredundant roles in promoting the clonal expansion of NK cells during viral infection.
- Migratory CD11b+ conventional dendritic cells induce T follicular helper cell–dependent antibody responses
Conventional DC2s are necessary and sufficient for priming T follicular helper cells.
- Sustained T follicular helper cell response is essential for control of chronic viral infection
CXCR5+ T follicular helper cells promote generation of neutralizing antibodies in response to chronic viral infection.
Editors' Choice
- Constant attack on T cell lymphomas
A proof-of-principle study generates CAR-T cells against T cell lymphoma by selectively targeting the T cell receptor β-chain constant region 1.
About The Cover
ONLINE COVER Priming T Follicular Helper Cells. A microscopic view of a lung-draining lymph node illustrating the differences in localization of CD11b+ type 2 conventional dendritic cells (cDC2s) and CD103+ type 1 conventional dendritic cells (cDC1s). cDC1s and cDC2s were stained with antibodies against CD11b (green) and CD103 (blue), and B cells were stained with anti-B220 antibody (red). Krishnaswamy et al. find that cDC2s are predominantly located in the T cell/B cell border area and are ideally positioned to prime T follicular helper cells. [CREDIT: J. MATTSSON/RIA, IMED BIOTECH UNIT, ASTRAZENECA]