Migratory CD11b+ conventional dendritic cells induce T follicular helper cell–dependent antibody responses

See allHide authors and affiliations

Science Immunology  01 Dec 2017:
Vol. 2, Issue 18, eaam9169
DOI: 10.1126/sciimmunol.aam9169

You are currently viewing the editor's summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

Priming T follicular helper cells

T follicular helper (Tfh) cells play an important role in modulating antibody production by B cells. Here, Krishnaswamy et al. have examined the ability of conventional dendritic cell (cDC) subsets to prime Tfh commitment in response to intranasal immunization in mice. They report that CD11b+ migratory type 2 cDCs (cDC2s) play an essential role in promoting commitment of activated T cells to the Tfh lineage. Using microscopy to study trafficking of cDC2s after intranasal immunization, the authors demonstrate that cDC2s have the ability to carry antigens to the T-B border of the lymph node where Tfh cell priming occurs. These findings have important implications on vaccine design and delivery.