Contents
January 2017
Vol 2, Issue 7
Vol 2, Issue 7
Perspective
- Listening to each other: Infectious disease and cancer immunology
Shared immunological principles influence design of immunotherapies for both cancer and infectious diseases.
Focus
- Retrieving short-term memories of flu
Circulating TEM constantly seed the lung TRM pool after influenza infection. See the related Research Article by Slütter et al.
Research Articles
- Low CD21 expression defines a population of recent germinal center graduates primed for plasma cell differentiation
A distinct population of B cells that respond to vaccination serve as potential plasma cell precursors.
- Potent and broad HIV-neutralizing antibodies in memory B cells and plasma
Plasma is a source of broadly neutralizing antibodies for recombinant antibodies with enhanced potency and breadth.
- Activation of mosquito complement antiplasmodial response requires cellular immunity
In malaria-infected mosquitoes, microvesicles from hemocytes activate complement to fight infection.
- Complement C5a receptor is the key initiator of neutrophil adhesion igniting immune complex–induced arthritis
C5aR directly initiates neutrophil adhesion required for immune complex–induced arthritis.
- Dynamics of influenza-induced lung-resident memory T cells underlie waning heterosubtypic immunity
Lung-resident memory T cell memory depends on reseeding from the circulating effector memory pool. See the Focus by Borges da Silva and Jameson.
- Tumor location determines tissue-specific recruitment of tumor-associated macrophages and antibody-dependent immunotherapy response
Tissue environment determines which immune effector cells contribute to tumor rejection by therapeutic antibodies.
About The Cover
ONLINE COVER TAMpering with tumors. Shown is FcγRIV expression (blue) on F4/80+ (green) and CD11b+ (red) macrophages in a subcutaneous melanoma tumor. Lehmann et al. show that different subtypes of these tumor-associated macrophages (TAMs) work with therapeutic antibodies depending on tumor location. [CREDIT: LEHMANN ET AL./SCIENCE IMMUNOLOGY]