Tumor location determines tissue-specific recruitment of tumor-associated macrophages and antibody-dependent immunotherapy response

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Science Immunology  06 Jan 2017:
Vol. 2, Issue 7, eaah6413
DOI: 10.1126/sciimmunol.aah6413

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TAMpering with tumors

Immunotherapeutic antibodies are a promising cancer therapy, but little is known about the nontargeted effects of these antibodies on immune cells through Fc receptor binding. Tumor-associated macrophages (TAMs) and tumor-associated neutrophils (TANs), which have been implicated in both promoting and inhibiting tumor growth, express abundant Fcγ receptors. Lehmann et al. examined these cells in tumors growing in different sites—skin and lung. They found that the organ environment in which a tumor grows determined which TAM and TAN subpopulations contributed to antibody-dependent tumor immunotherapy. Different cellular pathways underlay the antibody response in different tissues. These data may help fine-tune therapeutic strategies to target cells that promote tumors and not those that fight them.