Research ArticleHIV

Potent and broad HIV-neutralizing antibodies in memory B cells and plasma

See allHide authors and affiliations

Science Immunology  27 Jan 2017:
Vol. 2, Issue 7, eaal2200
DOI: 10.1126/sciimmunol.aal2200

You are currently viewing the editor's summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

Engineering HIV immunity

For rapidly mutating viruses such as HIV, antibodies that can neutralize more than one strain may have real potential as a therapeutic. Now, Williams et al. examine the ontogeny of broadly neutralizing antibodies (bnAbs) to the distal portion of the membrane-proximal external region (MPER) of HIV-1 gp41. They found similar clonal lineages of an MPER bnAb from both memory B cells and plasma, highlighting the viability of plasma as a source of bnAbs. These lineages shared an autoreactive unmutated common ancestor, suggesting that tolerance must be overcome for bnAb induction. The authors then engineered chimeric antibodies from the plasma and memory B cells that neutralized most HIV-1 strains.