Tracking the fate and origin of clinically relevant adoptively transferred CD8+ T cells in vivo

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Science Immunology  24 Feb 2017:
Vol. 2, Issue 8, eaal2568
DOI: 10.1126/sciimmunol.aal2568

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Tracking tumor immunity

Tumor-specific immune cells can lead to tumor regression in some cancer patients who do not respond to other therapies; however, the ability to track these cells after transfer has remained limited. Now, Chapuis et al. use high-throughput T cell receptor Vβ sequencing (HTTCS) to track individual clonotypes after transfer. They find that very low frequency clonotypes with proliferative and survival advantages can contribute to long-term tumor control. These data will help guide the selection of cell populations for immunotherapy.