Research ArticleINFECTIOUS DISEASE

Hypoxia determines survival outcomes of bacterial infection through HIF-1α–dependent reprogramming of leukocyte metabolism

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Science Immunology  10 Feb 2017:
Vol. 2, Issue 8, eaal2861
DOI: 10.1126/sciimmunol.aal2861

Article Information

vol. 2 no. 8

PubMed: 
Published By: 
History: 
  • Received June 1, 2016
  • Revision received October 26, 2016
  • Accepted December 23, 2016
  • .

Author Information

  1. A. A. Roger Thompson1,*,
  2. Rebecca S. Dickinson2,*,
  3. Fiona Murphy2,
  4. John P. Thomson3,
  5. Helen M. Marriott1,
  6. Adriana Tavares4,
  7. Joseph Willson2,
  8. Lynne Williams1,
  9. Amy Lewis1,
  10. Ananda Mirchandani2,
  11. Patricia Dos Santos Coelho2,
  12. Catherine Doherty2,
  13. Eilise Ryan2,
  14. Emily Watts2,
  15. Nicholas M. Morton4,
  16. Shareen Forbes4,
  17. Roland H. Stimson4,
  18. Abdul G. Hameed1,
  19. Nadine Arnold1,
  20. Julie A. Preston1,
  21. Allan Lawrie1,
  22. Veronica Finisguerra5,6,
  23. Massimiliano Mazzone5,6,
  24. Pranvera Sadiku2,
  25. Jermaine Goveia7,8,
  26. Federico Taverna7,8,
  27. Peter Carmeliet7,8,
  28. Simon J. Foster9,
  29. Edwin R. Chilvers10,
  30. Andrew S. Cowburn10,11,
  31. David H. Dockrell1,
  32. Randall S. Johnson11,
  33. Richard R. Meehan3,
  34. Moira K. B. Whyte2 and
  35. Sarah R. Walmsley2,
  1. 1Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, U.K.
  2. 2Medical Research Council/University of Edinburgh Centre for Inflammation Research, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, U.K.
  3. 3Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, U.K.
  4. 4University of Edinburgh/British Heart Foundation Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, U.K.
  5. 5Laboratory of Molecular Oncology and Angiogenesis, Vesalius Research Center, VIB, Leuven B3000, Belgium.
  6. 6Laboratory of Molecular Oncology and Angiogenesis, Vesalius Research Center, Department of Oncology, KU Leuven, Leuven B3000, Belgium.
  7. 7Laboratory of Angiogenesis and Vascular Metabolism, Vesalius Research Centre, VIB, Leuven B3000, Belgium.
  8. 8Laboratory of Angiogenesis and Vascular Metabolism, Vesalius Research Centre, KU Leuven, Leuven B3000, Belgium.
  9. 9Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield, U.K.
  10. 10Department of Medicine, University of Cambridge, Cambridge, U.K.
  11. 11Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, U.K.
  1. Corresponding author. Email: sarah.walmsley{at}ed.ac.uk
  1. * These authors contributed equally to this work.

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