Contents
Vol 2, Issue 9
Research Articles
- LAG3 limits regulatory T cell proliferation and function in autoimmune diabetes
Regulatory T cell–specific deletion of LAG3 in nonobese diabetic mice reduces the incidence of autoimmune diabetes.
- Host sirtuin 1 regulates mycobacterial immunopathogenesis and represents a therapeutic target against tuberculosis
Sirtuin 1 activation decreases lung pathology, reduces inflammation, and enhances drug efficacy against Mycobacterium tuberculosis.
- Up-regulation of LFA-1 allows liver-resident memory T cells to patrol and remain in the hepatic sinusoids
LFA-1 expression allows liver-resident CD8+ T cells to patrol hepatic sinusoids yet remain in the liver.
- Natural killer cell–mediated inflammation resolution is disabled in severe asthma
Severe asthma is characterized by decreased NK cell cytotoxicity, and corticosteroids further disable NK cell function.
- PPAR-γ promotes type 2 immune responses in allergy and nematode infection
PPAR-γ is critical for TH2 cell–mediated allergic inflammation and immunity to worm infection.
- Maintenance of macrophage transcriptional programs and intestinal homeostasis by epigenetic reader SP140
The epigenetic reader SP140, which is polymorphic in Crohn’s disease patients, regulates transcriptional programs in macrophages.
- Single-cell RNA-seq and computational analysis using temporal mixture modeling resolves TH1/TFH fate bifurcation in malaria
Computational modeling defines T helper cell differentiation toward multiple fates during experimental malaria.
Editors' Choice
- Help not wanted in the joint
A newly discovered T cell subset that helps B cells is expanded in joints of rheumatoid arthritis patients.
- It’s all in the family
CD70-deficiency causes primary immunodeficiency and susceptibility to EBV-driven lymphoma.
About The Cover

ONLINE COVER Combating colitis. Shown is a hematoxylin and eosin-stained section of distal colon tissue. Mehta et al. report that in macrophages the epigenetic reader SP140 maintains transcriptional programs that control intestinal homeostasis. Nonfunctional polymorphisms in SP140 associate with colitis in both mice and humans. [CREDIT: MEHTA ET AL./SCIENCE IMMUNOLOGY]