March 2017
Vol 2, Issue 9

About The Cover

Cover image expansion

ONLINE COVER Combating colitis. Shown is a hematoxylin and eosin-stained section of distal colon tissue. Mehta et al. report that in macrophages the epigenetic reader SP140 maintains transcriptional programs that control intestinal homeostasis. Nonfunctional polymorphisms in SP140 associate with colitis in both mice and humans. [CREDIT: MEHTA ET AL./SCIENCE IMMUNOLOGY]