Contents

Research Articles

• LAG3 limits regulatory T cell proliferation and function in autoimmune diabetes

  By Qianxia Zhang, Maria Chikina, Andrea L. Szymczak-Workman, William Horne, Jay K. Kolls, Kate M. Vignali, Daniel Normolle, Maria Bettini, Creg J. Workman, Dario A. A. Vignali

  Science Immunology31 Mar 2017 Full AccessRestricted Access

  Regulatory T cell–specific deletion of LAG3 in nonobese diabetic mice reduces the incidence of autoimmune diabetes.

  • Editor's Summary
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• Host sirtuin 1 regulates mycobacterial immunopathogenesis and represents a therapeutic target against tuberculosis

  By Catherine Y. Cheng, Nuria M. Gutierrez, Mardiana B. Marzuki, Xiaohua Lu, Taylor W. Foreman, Bhairav Paleja, Bernett Lee, Akhila Balachander, Jinmiao Chen, Liana Tsenova, Natalia Kurepina, Karen W. W. Teng, Kim West, Smriti Mehra, Francesca Zolezzi, Michael Poidinger, Barry Kreiswirth, Deepak Kaushal, Hardy Kornfeld, Evan W. Newell, Amit Singhal

  Science Immunology24 Mar 2017 Full AccessRestricted Access

  Sirtuin 1 activation decreases lung pathology, reduces inflammation, and enhances drug efficacy against Mycobacterium tuberculosis.

  • Editor's Summary
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• Up-regulation of LFA-1 allows liver-resident memory T cells to patrol and remain in the hepatic sinusoids

  By H. A. McNamara, Y. Cai, M. V. Wagle, Y. Sontani, C. M. Roots, L. A. Miosge, J. H. O’Connor, H. J. Sutton, V. V. Ganusov, W. R. Heath, P. Bertolino, C. G. Goodnow, I. A. Parish, A. Enders, I. A. Cockburn

  Science Immunology17 Mar 2017 Full AccessRestricted Access

  LFA-1 expression allows liver-resident CD8⁺ T cells to patrol hepatic sinusoids yet remain in the liver.

  • Editor's Summary
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• Natural killer cell–mediated inflammation resolution is disabled in severe asthma

  By Melody G. Duvall, Cindy Barnig, Manuela Cernadas, Isabell Ricklefs, Nandini Krishnamoorthy, Nicole L. Grossman, Nirav R. Bhakta, John V. Fahy, Eugene R. Bleecker, Mario Castro, Serpil C. Erzurum, Benjamin M. Gaston, Nizar N. Jarjour, David T. Mauger, Sally E. Wenzel, Suzy A. Comhair, Andrea M. Coverstone, Merritt L. Fajt, Annette T. Hastie, Mats W. Johansson, Michael C. Peters, Brenda R. Phillips, Elliot Israel, Bruce D. Levy, National Heart, Lung, and Blood Institute’s Severe Asthma Research Program-3 Investigators

  Science Immunology10 Mar 2017 Full AccessRestricted Access

  Severe asthma is characterized by decreased NK cell cytotoxicity, and corticosteroids further disable NK cell function.

  • Editor's Summary
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• PPAR-γ promotes type 2 immune responses in allergy and nematode infection

  By Ting Chen, Christopher A. Tibbitt, Xiaogang Feng, Julian M. Stark, Leona Rohrbeck, Lisa Rausch, Saikiran K. Sedimbi, Mikael C. I. Karlsson, Bart N. Lambrecht, Gunilla B. Karlsson Hedestam, Rudi W. Hendriks, Benedict J. Chambers, Susanne Nylén, Jonathan M. Coquet

  Science Immunology10 Mar 2017 Full AccessRestricted Access

  PPAR-γ is critical for T_H2 cell–mediated allergic inflammation and immunity to worm infection.

  • Editor's Summary
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• Maintenance of macrophage transcriptional programs and intestinal homeostasis by epigenetic reader SP140

  By Stuti Mehta, D. Alexander Cronkite, Megha Basavappa, Tahnee L. Saunders, Fatemeh Adiliaghdam, Hajera Amatullah, Sara A. Morrison, Jose D. Pagan, Robert M. Anthony, Pierre Tonnerre, Georg M. Lauer, James C. Lee, Sreehaas Digumarthi, Lorena Pantano, Shannan J. Ho Sui, Fei Ji, Ruslan Sadreyev, Chan Zhou, Alan C. Mullen, Vinod Kumar, Yang Li, Cisca Wijmenga, Ramnik J. Xavier, Terry K. Means, Kate L. Jeffrey

  Science Immunology03 Mar 2017 Full AccessRestricted Access

  The epigenetic reader SP140, which is polymorphic in Crohn’s disease patients, regulates transcriptional programs in macrophages.

  • Editor's Summary
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• Single-cell RNA-seq and computational analysis using temporal mixture modeling resolves T_H1/T_FH fate bifurcation in malaria

  By Tapio Lönnberg, Valentine Svensson, Kylie R. James, Daniel Fernandez-Ruiz, Ismail Sebina, Ruddy Montandon, Megan S. F. Soon, Lily G. Fogg, Arya Sheela Nair, Urijah N. Liligeto, Michael J. T. Stubbington, Lam-Ha Ly, Frederik Otzen Bagger, Max Zwiessele, Neil D. Lawrence, Fernando Souza-Fonseca-Guimaraes, Patrick T. Bunn, Christian R. Engwerda, William R. Heath, Oliver Billker, Oliver Stegle, Ashraful Haque, Sarah A. Teichmann

  Science Immunology03 Mar 2017 Full AccessRestricted Access

  Computational modeling defines T helper cell differentiation toward multiple fates during experimental malaria.

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• Editors' Choice

  • Help not wanted in the joint

    By Andrew H. Lichtman

    Science Immunology03 Mar 2017 Full AccessRestricted Access

    A newly discovered T cell subset that helps B cells is expanded in joints of rheumatoid arthritis patients.

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  • It’s all in the family

    By Gabriel K. Griffin

    Science Immunology03 Mar 2017 Full AccessRestricted Access

    CD70-deficiency causes primary immunodeficiency and susceptibility to EBV-driven lymphoma.

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