PPAR-γ promotes type 2 immune responses in allergy and nematode infection

Ting Chen; Christopher A. Tibbitt; Xiaogang Feng; Julian M. Stark; Leona Rohrbeck; Lisa Rausch; Saikiran K. Sedimbi; Mikael C. I. Karlsson; Bart N. Lambrecht; Gunilla B. Karlsson Hedestam; Rudi W. Hendriks; Benedict J. Chambers; Susanne Nylén; Jonathan M. Coquet

doi:10.1126/sciimmunol.aal5196

Research ArticleALLERGY

PPAR-γ promotes type 2 immune responses in allergy and nematode infection

View ORCID ProfileTing Chen¹,*,
Christopher A. Tibbitt¹,*,
Xiaogang Feng¹,†,
View ORCID ProfileJulian M. Stark¹,†,
Leona Rohrbeck¹,
Lisa Rausch¹,
Saikiran K. Sedimbi¹,
Mikael C. I. Karlsson¹,
Bart N. Lambrecht²,³,⁴,
Gunilla B. Karlsson Hedestam¹,
Rudi W. Hendriks⁴,
Benedict J. Chambers⁵,
Susanne Nylén¹ and
View ORCID ProfileJonathan M. Coquet¹,‡

¹Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm 171 77, Sweden.
²Laboratory of Immunoregulation, VIB Inflammation Research Center, Ghent 9052B, Belgium.
³Department of Respiratory Medicine, Ghent University Hospital, Ghent 9000, Belgium.
⁴Department of Pulmonary Medicine, Erasmus University Medical Center, Rotterdam, Netherlands.
⁵Department of Medicine, Center for Infectious Medicine, F59, Karolinska Institute, Karolinska University Hospital Huddinge, Huddinge, Sweden.

↵‡Corresponding author. Email: jonathan.coquet{at}ki.se

↵* These authors contributed equally to this work.
↵† These authors contributed equally to this work.

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Science Immunology 10 Mar 2017:
Vol. 2, Issue 9, eaal5196
DOI: 10.1126/sciimmunol.aal5196

Ting Chen

1Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm 171 77, Sweden.

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ORCID record for Ting Chen

Christopher A. Tibbitt

1Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm 171 77, Sweden.

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Xiaogang Feng

1Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm 171 77, Sweden.

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Julian M. Stark

1Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm 171 77, Sweden.

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Leona Rohrbeck

1Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm 171 77, Sweden.

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Lisa Rausch

1Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm 171 77, Sweden.

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Saikiran K. Sedimbi

1Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm 171 77, Sweden.

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Mikael C. I. Karlsson

1Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm 171 77, Sweden.

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Bart N. Lambrecht

2Laboratory of Immunoregulation, VIB Inflammation Research Center, Ghent 9052B, Belgium.

3Department of Respiratory Medicine, Ghent University Hospital, Ghent 9000, Belgium.

4Department of Pulmonary Medicine, Erasmus University Medical Center, Rotterdam, Netherlands.

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Gunilla B. Karlsson Hedestam

1Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm 171 77, Sweden.

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Rudi W. Hendriks

4Department of Pulmonary Medicine, Erasmus University Medical Center, Rotterdam, Netherlands.

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Benedict J. Chambers

5Department of Medicine, Center for Infectious Medicine, F59, Karolinska Institute, Karolinska University Hospital Huddinge, Huddinge, Sweden.

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Susanne Nylén

1Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm 171 77, Sweden.

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Jonathan M. Coquet

1Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm 171 77, Sweden.

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For correspondence: jonathan.coquet@ki.se

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PPAR-γ promotes type 2 immune responses in allergy and nematode infection

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