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Research ArticleTHYMUS
Production of BMP4 by endothelial cells is crucial for endogenous thymic regeneration
- View ORCID ProfileTobias Wertheimer1,2,*,
- View ORCID ProfileEnrico Velardi1,*,
- View ORCID ProfileJennifer Tsai1,3,*,
- View ORCID ProfileKirsten Cooper3,
- View ORCID ProfileShiyun Xiao4,
- View ORCID ProfileChristopher C. Kloss5,6,†,
- View ORCID ProfileKatja J. Ottmüller7,
- Zeinab Mokhtari7,
- Christian Brede7,
- Paul deRoos3,
- Sinéad Kinsella3,
- View ORCID ProfileBrisa Palikuqi5,
- Michael Ginsberg8,
- View ORCID ProfileLauren F. Young1,
- View ORCID ProfileFabiana Kreines1,
- Sophia R. Lieberman1,
- Amina Lazrak1,
- Peipei Guo5,
- View ORCID ProfileFlorent Malard1,
- Odette M. Smith1,
- View ORCID ProfileYusuke Shono1,
- View ORCID ProfileRobert R. Jenq9,
- View ORCID ProfileAlan M. Hanash9,
- View ORCID ProfileDaniel J. Nolan8,
- Jason M. Butler5,
- View ORCID ProfileAndreas Beilhack7,
- Nancy R. Manley4,
- Shahin Rafii5,
- View ORCID ProfileJarrod A. Dudakov3,10,‡,§ and
- View ORCID ProfileMarcel R. M. van den Brink1,9,‡,§
- 1Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
- 2Division of Hematology and Oncology, Department of Medicine, Freiburg University Medical Center, Albert-Ludwigs-University, 79106 Freiburg, Germany.
- 3Program in Immunology, Clinical Research Division, and Immunotherapy Integrated Research Center, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
- 4Department of Genetics, University of Georgia, Athens, GA 30602, USA.
- 5Department of Genetic Medicine and Ansary Stem Cell Institute, Weill Cornell Medical College, New York, NY 10021, USA.
- 6Center for Cell Engineering, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
- 7Department of Medicine II, Würzburg University Hospital, Interdisciplinary Center for Clinical Research (IZKF), and Graduate School of Life Sciences, University of Würzburg, Würzburg, Germany.
- 8Angiocrine Bioscience, San Diego, CA 92130, USA.
- 9Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
- 10Department of Immunology, University of Washington, Seattle, WA 98109, USA.
- ↵§Corresponding author. Email: jdudakov{at}fredhutch.org (J.A.D.); vandenbm{at}mskcc.org (M.R.M.v.d.B.)
↵* These authors contributed equally to this work.
↵‡ These authors contributed equally to this work.
↵† Present address: Center for Cellular Immunotherapies and Parker Institute for Cancer Immunotherapy, Perelman School of Medicine, University of Pennsylvania, PA 19104, USA.
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Science Immunology 12 Jan 2018:
Vol. 3, Issue 19, eaal2736
DOI: 10.1126/sciimmunol.aal2736
Vol. 3, Issue 19, eaal2736
DOI: 10.1126/sciimmunol.aal2736
Tobias Wertheimer
1Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
2Division of Hematology and Oncology, Department of Medicine, Freiburg University Medical Center, Albert-Ludwigs-University, 79106 Freiburg, Germany.
Enrico Velardi
1Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Jennifer Tsai
1Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
3Program in Immunology, Clinical Research Division, and Immunotherapy Integrated Research Center, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Kirsten Cooper
3Program in Immunology, Clinical Research Division, and Immunotherapy Integrated Research Center, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Shiyun Xiao
4Department of Genetics, University of Georgia, Athens, GA 30602, USA.
Christopher C. Kloss
5Department of Genetic Medicine and Ansary Stem Cell Institute, Weill Cornell Medical College, New York, NY 10021, USA.
6Center for Cell Engineering, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Katja J. Ottmüller
7Department of Medicine II, Würzburg University Hospital, Interdisciplinary Center for Clinical Research (IZKF), and Graduate School of Life Sciences, University of Würzburg, Würzburg, Germany.
Zeinab Mokhtari
7Department of Medicine II, Würzburg University Hospital, Interdisciplinary Center for Clinical Research (IZKF), and Graduate School of Life Sciences, University of Würzburg, Würzburg, Germany.
Christian Brede
7Department of Medicine II, Würzburg University Hospital, Interdisciplinary Center for Clinical Research (IZKF), and Graduate School of Life Sciences, University of Würzburg, Würzburg, Germany.
Paul deRoos
3Program in Immunology, Clinical Research Division, and Immunotherapy Integrated Research Center, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Sinéad Kinsella
3Program in Immunology, Clinical Research Division, and Immunotherapy Integrated Research Center, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Brisa Palikuqi
5Department of Genetic Medicine and Ansary Stem Cell Institute, Weill Cornell Medical College, New York, NY 10021, USA.
Michael Ginsberg
8Angiocrine Bioscience, San Diego, CA 92130, USA.
Lauren F. Young
1Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Fabiana Kreines
1Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Sophia R. Lieberman
1Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Amina Lazrak
1Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Peipei Guo
5Department of Genetic Medicine and Ansary Stem Cell Institute, Weill Cornell Medical College, New York, NY 10021, USA.
Florent Malard
1Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Odette M. Smith
1Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Yusuke Shono
1Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Robert R. Jenq
9Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Alan M. Hanash
9Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Daniel J. Nolan
8Angiocrine Bioscience, San Diego, CA 92130, USA.
Jason M. Butler
5Department of Genetic Medicine and Ansary Stem Cell Institute, Weill Cornell Medical College, New York, NY 10021, USA.
Andreas Beilhack
7Department of Medicine II, Würzburg University Hospital, Interdisciplinary Center for Clinical Research (IZKF), and Graduate School of Life Sciences, University of Würzburg, Würzburg, Germany.
Nancy R. Manley
4Department of Genetics, University of Georgia, Athens, GA 30602, USA.
Shahin Rafii
5Department of Genetic Medicine and Ansary Stem Cell Institute, Weill Cornell Medical College, New York, NY 10021, USA.
Jarrod A. Dudakov
3Program in Immunology, Clinical Research Division, and Immunotherapy Integrated Research Center, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
10Department of Immunology, University of Washington, Seattle, WA 98109, USA.
Marcel R. M. van den Brink
1Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
9Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
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