Production of BMP4 by endothelial cells is crucial for endogenous thymic regeneration

Tobias Wertheimer; Enrico Velardi; Jennifer Tsai; Kirsten Cooper; Shiyun Xiao; Christopher C. Kloss; Katja J. Ottmüller; Zeinab Mokhtari; Christian Brede; Paul deRoos; Sinéad Kinsella; Brisa Palikuqi; Michael Ginsberg; Lauren F. Young; Fabiana Kreines; Sophia R. Lieberman; Amina Lazrak; Peipei Guo; Florent Malard; Odette M. Smith; Yusuke Shono; Robert R. Jenq; Alan M. Hanash; Daniel J. Nolan; Jason M. Butler; Andreas Beilhack; Nancy R. Manley; Shahin Rafii; Jarrod A. Dudakov; Marcel R. M. van den Brink

doi:10.1126/sciimmunol.aal2736

Research ArticleTHYMUS

Production of BMP4 by endothelial cells is crucial for endogenous thymic regeneration

View ORCID ProfileTobias Wertheimer¹,²,*,
View ORCID ProfileEnrico Velardi¹,*,
View ORCID ProfileJennifer Tsai¹,³,*,
View ORCID ProfileKirsten Cooper³,
View ORCID ProfileShiyun Xiao⁴,
View ORCID ProfileChristopher C. Kloss⁵,⁶,†,
View ORCID ProfileKatja J. Ottmüller⁷,
Zeinab Mokhtari⁷,
Christian Brede⁷,
Paul deRoos³,
Sinéad Kinsella³,
View ORCID ProfileBrisa Palikuqi⁵,
Michael Ginsberg⁸,
View ORCID ProfileLauren F. Young¹,
View ORCID ProfileFabiana Kreines¹,
Sophia R. Lieberman¹,
Amina Lazrak¹,
Peipei Guo⁵,
View ORCID ProfileFlorent Malard¹,
Odette M. Smith¹,
View ORCID ProfileYusuke Shono¹,
View ORCID ProfileRobert R. Jenq⁹,
View ORCID ProfileAlan M. Hanash⁹,
View ORCID ProfileDaniel J. Nolan⁸,
Jason M. Butler⁵,
View ORCID ProfileAndreas Beilhack⁷,
Nancy R. Manley⁴,
Shahin Rafii⁵,
View ORCID ProfileJarrod A. Dudakov³,¹⁰,‡,§ and
View ORCID ProfileMarcel R. M. van den Brink¹,⁹,‡,§

¹Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
²Division of Hematology and Oncology, Department of Medicine, Freiburg University Medical Center, Albert-Ludwigs-University, 79106 Freiburg, Germany.
³Program in Immunology, Clinical Research Division, and Immunotherapy Integrated Research Center, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
⁴Department of Genetics, University of Georgia, Athens, GA 30602, USA.
⁵Department of Genetic Medicine and Ansary Stem Cell Institute, Weill Cornell Medical College, New York, NY 10021, USA.
⁶Center for Cell Engineering, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
⁷Department of Medicine II, Würzburg University Hospital, Interdisciplinary Center for Clinical Research (IZKF), and Graduate School of Life Sciences, University of Würzburg, Würzburg, Germany.
⁸Angiocrine Bioscience, San Diego, CA 92130, USA.
⁹Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
¹⁰Department of Immunology, University of Washington, Seattle, WA 98109, USA.

↵§Corresponding author. Email: jdudakov{at}fredhutch.org (J.A.D.); vandenbm{at}mskcc.org (M.R.M.v.d.B.)

↵* These authors contributed equally to this work.
↵‡ These authors contributed equally to this work.

↵† Present address: Center for Cellular Immunotherapies and Parker Institute for Cancer Immunotherapy, Perelman School of Medicine, University of Pennsylvania, PA 19104, USA.

See allHide authors and affiliations

Science Immunology 12 Jan 2018:
Vol. 3, Issue 19, eaal2736
DOI: 10.1126/sciimmunol.aal2736

Tobias Wertheimer

1Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

2Division of Hematology and Oncology, Department of Medicine, Freiburg University Medical Center, Albert-Ludwigs-University, 79106 Freiburg, Germany.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Tobias Wertheimer

Enrico Velardi

1Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Enrico Velardi

Jennifer Tsai

1Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

3Program in Immunology, Clinical Research Division, and Immunotherapy Integrated Research Center, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Jennifer Tsai

Kirsten Cooper

3Program in Immunology, Clinical Research Division, and Immunotherapy Integrated Research Center, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Kirsten Cooper

Shiyun Xiao

4Department of Genetics, University of Georgia, Athens, GA 30602, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Shiyun Xiao

Christopher C. Kloss

5Department of Genetic Medicine and Ansary Stem Cell Institute, Weill Cornell Medical College, New York, NY 10021, USA.

6Center for Cell Engineering, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Christopher C. Kloss

Katja J. Ottmüller

7Department of Medicine II, Würzburg University Hospital, Interdisciplinary Center for Clinical Research (IZKF), and Graduate School of Life Sciences, University of Würzburg, Würzburg, Germany.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Katja J. Ottmüller

Zeinab Mokhtari

7Department of Medicine II, Würzburg University Hospital, Interdisciplinary Center for Clinical Research (IZKF), and Graduate School of Life Sciences, University of Würzburg, Würzburg, Germany.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Christian Brede

7Department of Medicine II, Würzburg University Hospital, Interdisciplinary Center for Clinical Research (IZKF), and Graduate School of Life Sciences, University of Würzburg, Würzburg, Germany.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Paul deRoos

3Program in Immunology, Clinical Research Division, and Immunotherapy Integrated Research Center, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Sinéad Kinsella

3Program in Immunology, Clinical Research Division, and Immunotherapy Integrated Research Center, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Brisa Palikuqi

5Department of Genetic Medicine and Ansary Stem Cell Institute, Weill Cornell Medical College, New York, NY 10021, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Brisa Palikuqi

Michael Ginsberg

8Angiocrine Bioscience, San Diego, CA 92130, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Lauren F. Young

1Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Lauren F. Young

Fabiana Kreines

1Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Fabiana Kreines

Sophia R. Lieberman

1Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Amina Lazrak

1Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Peipei Guo

5Department of Genetic Medicine and Ansary Stem Cell Institute, Weill Cornell Medical College, New York, NY 10021, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Florent Malard

1Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Florent Malard

Odette M. Smith

1Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Yusuke Shono

1Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Yusuke Shono

Robert R. Jenq

9Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Robert R. Jenq

Alan M. Hanash

9Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Alan M. Hanash

Daniel J. Nolan

8Angiocrine Bioscience, San Diego, CA 92130, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Daniel J. Nolan

Jason M. Butler

5Department of Genetic Medicine and Ansary Stem Cell Institute, Weill Cornell Medical College, New York, NY 10021, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Andreas Beilhack

7Department of Medicine II, Würzburg University Hospital, Interdisciplinary Center for Clinical Research (IZKF), and Graduate School of Life Sciences, University of Würzburg, Würzburg, Germany.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Andreas Beilhack

Nancy R. Manley

4Department of Genetics, University of Georgia, Athens, GA 30602, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Shahin Rafii

5Department of Genetic Medicine and Ansary Stem Cell Institute, Weill Cornell Medical College, New York, NY 10021, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Jarrod A. Dudakov

3Program in Immunology, Clinical Research Division, and Immunotherapy Integrated Research Center, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

10Department of Immunology, University of Washington, Seattle, WA 98109, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Jarrod A. Dudakov
For correspondence: jdudakov@fredhutch.org vandenbm@mskcc.org

Marcel R. M. van den Brink

1Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

9Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Marcel R. M. van den Brink
For correspondence: jdudakov@fredhutch.org vandenbm@mskcc.org

Article
Figures & Data
Info & Metrics
eLetters
PDF

eLetters is an online forum for ongoing peer review. Submission of eLetters are open to all. eLetters are not edited, proofread, or indexed. Please read our Terms of Service before submitting your own eLetter.

Submit a Response to This Article

Compose eLetter

Title

Contents

More information about text formats

Plain text

Plain text
No HTML tags allowed.
Web page addresses and e-mail addresses turn into links automatically.
Lines and paragraphs break automatically.

Author Information

Contributors
First name and middle name First or given name, e.g. 'Peter'. Last Name Your last, or family, name, e.g. 'MacMoody'. Email Your email address, e.g. higgs-boson@gmail.com Role / Occupation Your role and/or occupation, e.g. 'Orthopedic Surgeon'. Affiliation Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.

Statement of Competing Interests

Competing interests?

Yes

Please describe the competing interests

CAPTCHA

This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

Vertical Tabs

No eLetters have been published for this article.

View Full Text

Production of BMP4 by endothelial cells is crucial for endogenous thymic regeneration

Plain text

Vertical Tabs

Science Immunology

Article Tools