Research ArticleANTIVIRAL IMMUNITY
Type I interferons instigate fetal demise after Zika virus infection
- Laura J. Yockey1,
- Kellie A. Jurado1,
- Nitin Arora2,
- Alon Millet1,
- Tasfia Rakib1,
- Kristin M. Milano3,
- Andrew K. Hastings4,
- Erol Fikrig4,5,
- Yong Kong6,
- Tamas L. Horvath7,
- Scott Weatherbee8,
- Harvey J. Kliman3,
- Carolyn B. Coyne2,9 and
- Akiko Iwasaki1,5,*
- 1Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.
- 2Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA.
- 3Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520, USA.
- 4Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA.
- 5Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.
- 6Yale School of Public Health, New Haven, CT 06520, USA.
- 7Program in Integrative Cell Signaling and Neurobiology of Metabolism, Section of Comparative Medicine New Haven, CT 06520, USA.
- 8Department of Genetics, Yale University School of Medicine, New Haven, CT 06520, USA.
- 9Center for Microbial Pathogenesis, Children’s Hospital of Pittsburgh of UPMC (University of Pittsburgh Medical Center), Pittsburgh, PA 15224, USA.
- ↵*Corresponding author. Email: akiko.iwasaki{at}yale.edu
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Science Immunology 05 Jan 2018:
Vol. 3, Issue 19, eaao1680
DOI: 10.1126/sciimmunol.aao1680
Vol. 3, Issue 19, eaao1680
DOI: 10.1126/sciimmunol.aao1680
Laura J. Yockey
Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.
Kellie A. Jurado
Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.
Nitin Arora
Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA.
Alon Millet
Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.
Tasfia Rakib
Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.
Kristin M. Milano
Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520, USA.
Andrew K. Hastings
Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA.
Erol Fikrig
Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA.Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.
Yong Kong
Yale School of Public Health, New Haven, CT 06520, USA.
Tamas L. Horvath
Program in Integrative Cell Signaling and Neurobiology of Metabolism, Section of Comparative Medicine New Haven, CT 06520, USA.
Scott Weatherbee
Department of Genetics, Yale University School of Medicine, New Haven, CT 06520, USA.
Harvey J. Kliman
Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520, USA.
Carolyn B. Coyne
Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA.Center for Microbial Pathogenesis, Children’s Hospital of Pittsburgh of UPMC (University of Pittsburgh Medical Center), Pittsburgh, PA 15224, USA.
Akiko Iwasaki
Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.
