Research ArticleANTIVIRAL IMMUNITY
Type I interferons instigate fetal demise after Zika virus infection
- View ORCID ProfileLaura J. Yockey1,
- Kellie A. Jurado1,
- Nitin Arora2,
- View ORCID ProfileAlon Millet1,
- View ORCID ProfileTasfia Rakib1,
- Kristin M. Milano3,
- View ORCID ProfileAndrew K. Hastings4,
- View ORCID ProfileErol Fikrig4,5,
- View ORCID ProfileYong Kong6,
- Tamas L. Horvath7,
- Scott Weatherbee8,
- View ORCID ProfileHarvey J. Kliman3,
- View ORCID ProfileCarolyn B. Coyne2,9 and
- View ORCID ProfileAkiko Iwasaki1,5,*
- 1Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.
- 2Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA.
- 3Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520, USA.
- 4Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA.
- 5Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.
- 6Yale School of Public Health, New Haven, CT 06520, USA.
- 7Program in Integrative Cell Signaling and Neurobiology of Metabolism, Section of Comparative Medicine New Haven, CT 06520, USA.
- 8Department of Genetics, Yale University School of Medicine, New Haven, CT 06520, USA.
- 9Center for Microbial Pathogenesis, Children’s Hospital of Pittsburgh of UPMC (University of Pittsburgh Medical Center), Pittsburgh, PA 15224, USA.
- ↵*Corresponding author. Email: akiko.iwasaki{at}yale.edu
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Science Immunology 05 Jan 2018:
Vol. 3, Issue 19, eaao1680
DOI: 10.1126/sciimmunol.aao1680
Vol. 3, Issue 19, eaao1680
DOI: 10.1126/sciimmunol.aao1680
Laura J. Yockey
1Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.
Kellie A. Jurado
1Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.
Nitin Arora
2Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA.
Alon Millet
1Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.
Tasfia Rakib
1Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.
Kristin M. Milano
3Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520, USA.
Andrew K. Hastings
4Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA.
Erol Fikrig
4Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA.
5Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.
Yong Kong
6Yale School of Public Health, New Haven, CT 06520, USA.
Tamas L. Horvath
7Program in Integrative Cell Signaling and Neurobiology of Metabolism, Section of Comparative Medicine New Haven, CT 06520, USA.
Scott Weatherbee
8Department of Genetics, Yale University School of Medicine, New Haven, CT 06520, USA.
Harvey J. Kliman
3Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520, USA.
Carolyn B. Coyne
2Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA.
9Center for Microbial Pathogenesis, Children’s Hospital of Pittsburgh of UPMC (University of Pittsburgh Medical Center), Pittsburgh, PA 15224, USA.
Akiko Iwasaki
1Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.
5Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.
