Contents
February 2018
Vol 3, Issue 20
Vol 3, Issue 20
Focus
- Who let the dogs out? The ever-present threat of autoreactive T cells
Islet-reactive cytotoxic CD8+ T cells home to the pancreas in type 1 diabetes but circulate at similar frequencies in patients and healthy controls. See the related research article by Culina et al.
Research Articles
- Dysregulated invertebrate tropomyosin–dectin-1 interaction confers susceptibility to allergic diseases
Invertebrate tropomyosin homologs are ligands for dectin-1.
- Clonal selection drives protective memory B cell responses in controlled human malaria infection
The clonal selection of potent germline antibodies outpaces affinity maturation in human anti-PfCSP memory B cell responses.
- Islet-reactive CD8+ T cell frequencies in the pancreas, but not in blood, distinguish type 1 diabetic patients from healthy donors
Islet-reactive CD8+ T cells are common in the periphery, but home to the pancreas preferentially in the context of type 1 diabetes.
Reviews
- Essential immunologic orchestrators of intestinal homeostasis
This Review discusses how seminal findings have shaped our current understanding of homeostasis and host-microbiota interactions in the mammalian intestine.
- Causal effects of the microbiota on immune-mediated diseases
This Review summarizes current strategies for modeling host-microbiome interactions in the mammalian gastrointestinal tract.
Editors' Choice
- Flora-ishing guts assist cancer immunotherapies
Gut bacteria influence patient response to cancer therapy.
- What can I TIL you? Decoding TCR antigens.
Novel unbiased strategy for identification of peptide antigens bound by tumor-infiltrating lymphocyte T cell receptors.
About The Cover
ONLINE COVER Finding the Islets. Shown on the cover is the location of the human pancreas. Culina et al. show that although islet-reactive T cells are present in peripheral circulation in healthy individuals and in type 1 diabetics, these T cells home to the pancreas only in diabetic individuals. Their findings suggest that the ability of these islet-reactive T cells to infiltrate the pancreas is a hallmark of type 1 diabetes. [CREDIT: ISTOCK.COM/NERTHUZ]