Neuropilin-1 expression in adipose tissue macrophages protects against obesity and metabolic syndrome

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Science Immunology  16 Mar 2018:
Vol. 3, Issue 21, eaan4626
DOI: 10.1126/sciimmunol.aan4626

Keeping the calm in the adipose tissue

Obesity is associated with chronic inflammation and accumulation of immune cells in adipose tissue. Here, Wilson et al. report that macrophages that express neuropilin-1 (NRP1) play an essential role in limiting obesity-associated inflammation. In mice placed on a high-fat diet, deletion of NRP1 in myeloid cells accelerated both weight gain and development of insulin resistance. The authors found that NRP1 regulated fatty acid uptake in macrophages and that deficiency of NRP1 skewed their metabolism toward glycolysis, which is associated with a more aggressive inflammation. The studies add to the growing recognition of the importance of immune cells in obesity and other metabolic syndromes.

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