Neuropilin-1 expression in adipose tissue macrophages protects against obesity and metabolic syndrome

Ariel Molly Wilson; Zhuo Shao; Vanessa Grenier; Gaëlle Mawambo; Jean-François Daudelin; Agnieszka Dejda; Frédérique Pilon; Natalija Popovic; Salix Boulet; Célia Parinot; Malika Oubaha; Nathalie Labrecque; Vincent de Guire; Mathieu Laplante; Guillaume Lettre; Florian Sennlaub; Jean-Sebastien Joyal; Michel Meunier; Przemyslaw Sapieha

doi:10.1126/sciimmunol.aan4626

Research ArticleMETABOLIC DISEASE

Neuropilin-1 expression in adipose tissue macrophages protects against obesity and metabolic syndrome

Ariel Molly Wilson¹,²,
Zhuo Shao¹,
Vanessa Grenier¹,
Gaëlle Mawambo¹,
Jean-François Daudelin³,
Agnieszka Dejda¹,⁴,
Frédérique Pilon⁴,
Natalija Popovic⁴,
Salix Boulet³,
Célia Parinot¹,
Malika Oubaha¹,
Nathalie Labrecque³,
Vincent de Guire¹,
Mathieu Laplante⁵,
Guillaume Lettre⁶,
Florian Sennlaub⁷,
Jean-Sebastien Joyal⁸,
Michel Meunier² and
Przemyslaw Sapieha¹,⁴,*

¹Department of Biochemistry, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec H1T 2M4, Canada.
²Department of Engineering Physics, École Polytechnique de Montréal, Montreal, Quebec H3T 1J4, Canada.
³Department of Microbiology, Infectiology and Immunology, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec H1T 2M4, Canada.
⁴Department of Ophthalmology, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec H1T 2M4, Canada.
⁵Centre de recherche de l’Institut universitaire de cardiologie et de pneumologie de Québec (CRIUCPQ), Université Laval, Faculté de médecine, 2725 Chemin Ste-Foy, Quebec, Quebec G1V 4G5, Canada.
⁶Montreal Heart Institute, Université de Montréal, Montreal, Quebec H1T 1C8, Canada.
⁷Institut de la Vision, Institut National de la Santé et de la Recherche Médicale, U 968, Paris F-75012, France.
⁸Departments of Pediatrics, Ophthalmology, and Pharmacology, Centre Hospitalier Universitaire Ste-Justine Research Center, Université de Montréal, Montreal, Quebec H1T 2M4, Canada.

↵*Corresponding author. Email: mike.sapieha{at}umontreal.ca

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Science Immunology 16 Mar 2018:
Vol. 3, Issue 21, eaan4626
DOI: 10.1126/sciimmunol.aan4626

Ariel Molly Wilson

Department of Biochemistry, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec H1T 2M4, Canada.Department of Engineering Physics, École Polytechnique de Montréal, Montreal, Quebec H3T 1J4, Canada.

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Zhuo Shao

Department of Biochemistry, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec H1T 2M4, Canada.

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Vanessa Grenier

Department of Biochemistry, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec H1T 2M4, Canada.

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ORCID record for Vanessa Grenier

Gaëlle Mawambo

Department of Biochemistry, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec H1T 2M4, Canada.

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Jean-François Daudelin

Department of Microbiology, Infectiology and Immunology, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec H1T 2M4, Canada.

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Agnieszka Dejda

Department of Biochemistry, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec H1T 2M4, Canada.Department of Ophthalmology, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec H1T 2M4, Canada.

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Frédérique Pilon

Department of Ophthalmology, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec H1T 2M4, Canada.

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Natalija Popovic

Department of Ophthalmology, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec H1T 2M4, Canada.

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ORCID record for Natalija Popovic

Salix Boulet

Department of Microbiology, Infectiology and Immunology, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec H1T 2M4, Canada.

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Célia Parinot

Department of Biochemistry, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec H1T 2M4, Canada.

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Malika Oubaha

Department of Biochemistry, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec H1T 2M4, Canada.

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Nathalie Labrecque

Department of Microbiology, Infectiology and Immunology, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec H1T 2M4, Canada.

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Vincent de Guire

Department of Biochemistry, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec H1T 2M4, Canada.

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Mathieu Laplante

Centre de recherche de l’Institut universitaire de cardiologie et de pneumologie de Québec (CRIUCPQ), Université Laval, Faculté de médecine, 2725 Chemin Ste-Foy, Quebec, Quebec G1V 4G5, Canada.

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Guillaume Lettre

Montreal Heart Institute, Université de Montréal, Montreal, Quebec H1T 1C8, Canada.

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Florian Sennlaub

Institut de la Vision, Institut National de la Santé et de la Recherche Médicale, U 968, Paris F-75012, France.

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Jean-Sebastien Joyal

Departments of Pediatrics, Ophthalmology, and Pharmacology, Centre Hospitalier Universitaire Ste-Justine Research Center, Université de Montréal, Montreal, Quebec H1T 2M4, Canada.

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Michel Meunier

Department of Engineering Physics, École Polytechnique de Montréal, Montreal, Quebec H3T 1J4, Canada.

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Przemyslaw Sapieha

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For correspondence: mike.sapieha@umontreal.ca

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Neuropilin-1 expression in adipose tissue macrophages protects against obesity and metabolic syndrome

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