Contents
April 2018
Vol 3, Issue 22
Vol 3, Issue 22
Editorial
- Charting new horizons for Science Immunology
A new Editor takes up the baton at Science Immunology.
Research Articles
- Transcription factor ID2 prevents E proteins from enforcing a naïve T lymphocyte gene program during NK cell development
NK cell maturation depends on transcription factor ID2 blocking acquisition of a naïve T cell gene program.
- Tumor suppressor BAP1 is essential for thymic development and proliferative responses of T lymphocytes
The nuclear deubiquitinase BAP1 promotes cell cycle progression and expansion in thymocytes and in peripheral T cells.
- Platelets expressing IgG receptor FcγRIIA/CD32A determine the severity of experimental anaphylaxis
Platelet-derived serotonin contributes to FcγRIIA/CD32A-induced IgG-dependent anaphylaxis.
- The receptor repertoire and functional profile of follicular T cells in HIV-infected lymph nodes
Follicular T cells undergo clonal expansion and express an altered functional phenotype during chronic HIV infection.
Editors' Choice
- “That’s not helping”–T follicular helper cells drive skin fibrosis
T follicular helper–like cells and IL-21 are drivers of skin fibrosis in systemic sclerosis.
- The right angle on IL-2 therapy
Engineered cytokines are able to improve immunotherapy in mouse tumor models.
About The Cover
ONLINE COVER Cellular Blackjack. Shown is a dot plot pinpointing the location of interleukin-21(IL-21)–producing cells (black dots) among nine clusters of follicular helper T (TFH) cells in lymph nodes from HIV-infected humans. Wendel et al. find that chronic HIV infection is associated with emergence of an excess of activated TFH cells secreting IL-21. [CREDIT: B. S. WENDEL ET AL./SCIENCE IMMUNOLOGY]