April 2018
Vol 3, Issue 22

About The Cover

Cover image expansion

ONLINE COVER Cellular Blackjack. Shown is a dot plot pinpointing the location of interleukin-21(IL-21)–producing cells (black dots) among nine clusters of follicular helper T (TFH) cells in lymph nodes from HIV-infected humans. Wendel et al. find that chronic HIV infection is associated with emergence of an excess of activated TFH cells secreting IL-21. [CREDIT: B. S. WENDEL ET AL./SCIENCE IMMUNOLOGY]