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Platelets expressing IgG receptor FcγRIIA/CD32A determine the severity of experimental anaphylaxis

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Science Immunology  13 Apr 2018:
Vol. 3, Issue 22, eaan5997
DOI: 10.1126/sciimmunol.aan5997

Article Information

vol. 3 no. 22

PubMed: 
Published By: 
History: 
  • Received May 7, 2017
  • Revision received December 4, 2017
  • Accepted February 16, 2018
  • .

Author Information

  1. Héloïse Beutier1,2,3,*,
  2. Béatrice Hechler4,*,
  3. Ophélie Godon1,2,
  4. Yu Wang1,2,5,
  5. Caitlin M. Gillis1,2,3,
  6. Luc de Chaisemartin6,7,
  7. Aurélie Gouel-Chéron1,2,8,
  8. Stéphanie Magnenat4,
  9. Lynn E. Macdonald9,
  10. Andrew J. Murphy9,
  11. NASA study group,
  12. Sylvie Chollet-Martin6,7,
  13. Dan Longrois8,10,
  14. Christian Gachet4,
  15. Pierre Bruhns1,2, and
  16. Friederike Jönsson1,2,
  1. 1Institut Pasteur, Department of Immunology, Unit of Antibodies in Therapy and Pathology, Paris, France.
  2. 2INSERM U1222, Paris, France.
  3. 3Université Pierre et Marie Curie, Paris, France.
  4. 4Université de Strasbourg, INSERM, Etablissement Français du Sang (EFS) Grand Est, Biologie et Pharmacologie des plaquettes sanguines (BPPS) UMR_S1255, Fédération de Médecine Translationnelle de Strasbourg (FMTS), F-67000 Strasbourg, France.
  5. 5Université Diderot Paris VII, Paris, France.
  6. 6Unité Fonctionnelle Auto-immunité et Hypersensibilités, Hôpital Bichat, Assistance Publique–Hôpitaux de Paris (AP-HP), Paris, France.
  7. 7UMR996—Inflammation, Chemokines et Immunopathology, INSERM, Université Paris-Sud, Université Paris-Saclay, Châtenay-Malabry, France.
  8. 8Département d’Anesthésie-Réanimation, Hôpital Bichat, AP-HP, Paris, France.
  9. 9Regeneron Pharmaceuticals Inc., Tarrytown, NY 10591, USA.
  10. 10INSERM UMR1152, Université Paris Diderot Paris 7, Paris, France.
  1. Corresponding author. Email: joensson{at}pasteur.fr (F.J.); bruhns{at}pasteur.fr (P.B.)
  1. * These authors contributed equally to this work.

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