Platelets expressing IgG receptor FcγRIIA/CD32A determine the severity of experimental anaphylaxis

Héloïse Beutier; Béatrice Hechler; Ophélie Godon; Yu Wang; Caitlin M. Gillis; Luc de Chaisemartin; Aurélie Gouel-Chéron; Stéphanie Magnenat; Lynn E. Macdonald; Andrew J. Murphy; NASA study group; Sylvie Chollet-Martin; Dan Longrois; Christian Gachet; Pierre Bruhns; Friederike Jönsson

doi:10.1126/sciimmunol.aan5997

Research ArticleALLERGY

Platelets expressing IgG receptor FcγRIIA/CD32A determine the severity of experimental anaphylaxis

Héloïse Beutier¹,²,³,*,
Béatrice Hechler⁴,*,
Ophélie Godon¹,²,
Yu Wang¹,²,⁵,
Caitlin M. Gillis¹,²,³,
Luc de Chaisemartin⁶,⁷,
Aurélie Gouel-Chéron¹,²,⁸,
Stéphanie Magnenat⁴,
Lynn E. Macdonald⁹,
Andrew J. Murphy⁹,
NASA study group†,
Sylvie Chollet-Martin⁶,⁷,
Dan Longrois⁸,¹⁰,
Christian Gachet⁴,
Pierre Bruhns ¹,²,‡ and
Friederike Jönsson ¹,²,‡

¹Institut Pasteur, Department of Immunology, Unit of Antibodies in Therapy and Pathology, Paris, France.
²INSERM U1222, Paris, France.
³Université Pierre et Marie Curie, Paris, France.
⁴Université de Strasbourg, INSERM, Etablissement Français du Sang (EFS) Grand Est, Biologie et Pharmacologie des plaquettes sanguines (BPPS) UMR_S1255, Fédération de Médecine Translationnelle de Strasbourg (FMTS), F-67000 Strasbourg, France.
⁵Université Diderot Paris VII, Paris, France.
⁶Unité Fonctionnelle Auto-immunité et Hypersensibilités, Hôpital Bichat, Assistance Publique–Hôpitaux de Paris (AP-HP), Paris, France.
⁷UMR996—Inflammation, Chemokines et Immunopathology, INSERM, Université Paris-Sud, Université Paris-Saclay, Châtenay-Malabry, France.
⁸Département d’Anesthésie-Réanimation, Hôpital Bichat, AP-HP, Paris, France.
⁹Regeneron Pharmaceuticals Inc., Tarrytown, NY 10591, USA.
¹⁰INSERM UMR1152, Université Paris Diderot Paris 7, Paris, France.

↵‡Corresponding author. Email: joensson{at}pasteur.fr (F.J.); bruhns{at}pasteur.fr (P.B.)

↵* These authors contributed equally to this work.

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Science Immunology 13 Apr 2018:
Vol. 3, Issue 22, eaan5997
DOI: 10.1126/sciimmunol.aan5997

Héloïse Beutier

Institut Pasteur, Department of Immunology, Unit of Antibodies in Therapy and Pathology, Paris, France.INSERM U1222, Paris, France.Université Pierre et Marie Curie, Paris, France.

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Béatrice Hechler

Université de Strasbourg, INSERM, Etablissement Français du Sang (EFS) Grand Est, Biologie et Pharmacologie des plaquettes sanguines (BPPS) UMR_S1255, Fédération de Médecine Translationnelle de Strasbourg (FMTS), F-67000 Strasbourg, France.

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Ophélie Godon

Institut Pasteur, Department of Immunology, Unit of Antibodies in Therapy and Pathology, Paris, France.INSERM U1222, Paris, France.

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Yu Wang

Institut Pasteur, Department of Immunology, Unit of Antibodies in Therapy and Pathology, Paris, France.INSERM U1222, Paris, France.Université Diderot Paris VII, Paris, France.

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Caitlin M. Gillis

Institut Pasteur, Department of Immunology, Unit of Antibodies in Therapy and Pathology, Paris, France.INSERM U1222, Paris, France.Université Pierre et Marie Curie, Paris, France.

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Luc de Chaisemartin

Unité Fonctionnelle Auto-immunité et Hypersensibilités, Hôpital Bichat, Assistance Publique–Hôpitaux de Paris (AP-HP), Paris, France.UMR996—Inflammation, Chemokines et Immunopathology, INSERM, Université Paris-Sud, Université Paris-Saclay, Châtenay-Malabry, France.

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Aurélie Gouel-Chéron

Institut Pasteur, Department of Immunology, Unit of Antibodies in Therapy and Pathology, Paris, France.INSERM U1222, Paris, France.Département d’Anesthésie-Réanimation, Hôpital Bichat, AP-HP, Paris, France.

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Stéphanie Magnenat

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Lynn E. Macdonald

Regeneron Pharmaceuticals Inc., Tarrytown, NY 10591, USA.

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Andrew J. Murphy

Regeneron Pharmaceuticals Inc., Tarrytown, NY 10591, USA.

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Sylvie Chollet-Martin

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Dan Longrois

Département d’Anesthésie-Réanimation, Hôpital Bichat, AP-HP, Paris, France.INSERM UMR1152, Université Paris Diderot Paris 7, Paris, France.

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Christian Gachet

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Pierre Bruhns

Institut Pasteur, Department of Immunology, Unit of Antibodies in Therapy and Pathology, Paris, France.INSERM U1222, Paris, France.

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For correspondence: joensson@pasteur.fr bruhns@pasteur.fr

Friederike Jönsson

Institut Pasteur, Department of Immunology, Unit of Antibodies in Therapy and Pathology, Paris, France.INSERM U1222, Paris, France.

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For correspondence: joensson@pasteur.fr bruhns@pasteur.fr

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Platelets expressing IgG receptor FcγRIIA/CD32A determine the severity of experimental anaphylaxis

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