June 2018
Vol 3, Issue 24
  • Focus

  • Research Articles

    • Mitochondria maintain controlled activation state of epithelial-resident T lymphocytes

      The semi-activation state of IELs is maintained by an altered cardiolipin makeup of their mitochondrial membranes.

    • A recessive form of hyper-IgE syndrome by disruption of ZNF341-dependent STAT3 transcription and activity

      ZNF341 is a newly characterized transcription factor controlling baseline and inducible transcription of the human STAT3 gene.

    • ZNF341 controls STAT3 expression and thereby immunocompetence

      Homozygous nonsense mutations in ZNF341 impair its ability to activate STAT3 transcription and thereby cause immunodeficiency.

    • CD4+ T cell–mediated HLA class II cross-restriction in HIV controllers

      The structural basis of HIV-Gag recognition by class II–restricted T cell receptors in spontaneous controllers.

    • Identification and characterization of HIV-specific resident memory CD8+ T cells in human lymphoid tissue

      Resident memory T cells in lymphoid tissues help restrain HIV replication in elite controllers.

  • Editors' Choice

About The Cover

Cover image expansion

ONLINE COVER Defenders in residence. Buggert et al. report that HIV-specific resident memory CD8+ T cells are a central component of antiviral surveillance in HIV-infected lymphoid tissue. Featured on the cover is a confocal microscopic image demonstrating the presence of resident memory CD8+ T cells in a cervical lymph node section from an HIV-infected individual stained with antibodies against CD8 (green), CD69 (red), and CD103 (pink) to identify resident memory CD8+ T cells and CD20 (light blue) to demarcate lymphoid follicles (nuclear staining is shown in blue). [CREDIT: CONSTANTINOS PETROVAS]