Contents
June 2018
Vol 3, Issue 24
Vol 3, Issue 24
Focus
- Who regulates whom: ZNF341 is an additional player in the STAT3/TH17 song
Deficiency of ZNF341, a transcription factor featuring 12 Cys2His2 zinc fingers that regulates the expression and autoinduction of STAT3 (signal transducer and activator of transcription 3), results in hyper–immunoglobulin E syndrome and defective T helper 17 cell differentiation in humans.
- Resident T cells stand up to HIV
HIV-specific resident memory T cells are abundant in lymphoid tissues of elite controllers and exhibit distinct functional properties. See related research article by Buggert et al.
Research Articles
- Mitochondria maintain controlled activation state of epithelial-resident T lymphocytes
The semi-activation state of IELs is maintained by an altered cardiolipin makeup of their mitochondrial membranes.
- A recessive form of hyper-IgE syndrome by disruption of ZNF341-dependent STAT3 transcription and activity
ZNF341 is a newly characterized transcription factor controlling baseline and inducible transcription of the human STAT3 gene.
- ZNF341 controls STAT3 expression and thereby immunocompetence
Homozygous nonsense mutations in ZNF341 impair its ability to activate STAT3 transcription and thereby cause immunodeficiency.
- CD4+ T cell–mediated HLA class II cross-restriction in HIV controllers
The structural basis of HIV-Gag recognition by class II–restricted T cell receptors in spontaneous controllers.
- Identification and characterization of HIV-specific resident memory CD8+ T cells in human lymphoid tissue
Resident memory T cells in lymphoid tissues help restrain HIV replication in elite controllers.
Editors' Choice
- Bats are “blind” to the deadly effects of viruses
Bats that harbor lethal viruses avoid disease through an evolved antiviral defense strategy that leverages tolerance for infections.
- Bigger and better in Tex’s
High-dimensional profiling defines novel metrics of T cell exhaustion in HIV and cancer.
About The Cover
ONLINE COVER Defenders in residence. Buggert et al. report that HIV-specific resident memory CD8+ T cells are a central component of antiviral surveillance in HIV-infected lymphoid tissue. Featured on the cover is a confocal microscopic image demonstrating the presence of resident memory CD8+ T cells in a cervical lymph node section from an HIV-infected individual stained with antibodies against CD8 (green), CD69 (red), and CD103 (pink) to identify resident memory CD8+ T cells and CD20 (light blue) to demarcate lymphoid follicles (nuclear staining is shown in blue). [CREDIT: CONSTANTINOS PETROVAS]