Research ArticleT CELL ACTIVATION

Mitochondria maintain controlled activation state of epithelial-resident T lymphocytes

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Science Immunology  22 Jun 2018:
Vol. 3, Issue 24, eaan2543
DOI: 10.1126/sciimmunol.aan2543

Controlled activation

At the intestinal barrier, lymphocyte activation is a tightly regulated process that enables rapid responses to pathogens but avoids destructive inflammation. Konjar et al. examine how intraepithelial lymphocytes (IELs) maintain a controlled activation state, which is influenced by the composition of the mitochondrial membrane. Inflammation triggers changes in the mitochondrial membranes of IELs, particularly the cardiolipin composition, and these changes support rapid proliferation and effector functions. These findings reveal a role for mitochondria in controlling the activation state of IELs, thus furthering our insights into how mitochondria can influence immune responses.

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