Research ArticleIMMUNODEFICIENCIES

ZNF341 controls STAT3 expression and thereby immunocompetence

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Science Immunology  15 Jun 2018:
Vol. 3, Issue 24, eaat4941
DOI: 10.1126/sciimmunol.aat4941

Fingers on the trigger

Hyper–immunoglobulin E syndromes (HIESs) are rare genetic immunodeficiency diseases characterized by bacterial infections, chronic mucocutaneous candidiasis, allergies, and skeletal abnormalities that are associated with excessive TH2 responses and impaired TH17 immunity. Béziat et al. and Frey-Jakobs et al. have studied patients with an autosomal recessive form of HIES and identified mutations in the zinc finger transcription factor ZNF341 as the culprit. Loss-of-function mutations encoding truncated forms of ZNF341 interfered with its ability to recognize a bipartite binding site located in the promoter of STAT3, the transcription factor mutated in most cases of autosomal dominant HIES. ZNF341-supported transcription of STAT3 is a key upstream regulatory step needed to trigger the normal induction of the TH17 differentiation pathway. These findings reveal a previously unappreciated layer of transcriptional regulation controlling JAK-STAT signaling.

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