ZNF341 controls STAT3 expression and thereby immunocompetence

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Science Immunology  15 Jun 2018:
Vol. 3, Issue 24, eaat4941
DOI: 10.1126/sciimmunol.aat4941

Article Information

vol. 3 no. 24

Published By: 
  • Received March 5, 2018
  • Accepted May 17, 2018
  • .

Author Information

  1. Stefanie Frey-Jakobs1,*,
  2. Julia M. Hartberger1,*,
  3. Manfred Fliegauf1,*,
  4. Claudia Bossen1,*,
  5. Magdalena L. Wehmeyer1,
  6. Johanna C. Neubauer1,
  7. Alla Bulashevska1,
  8. Michele Proietti1,
  9. Philipp Fröbel1,
  10. Christina Nöltner1,
  11. Linlin Yang1,
  12. Jessica Rojas-Restrepo1,
  13. Niko Langer1,
  14. Sandra Winzer1,
  15. Karin R. Engelhardt2,
  16. Cristina Glocker1,,
  17. Dietmar Pfeifer3,
  18. Adi Klein4,
  19. Alejandro A. Schäffer5,
  20. Irina Lagovsky6,7,
  21. Idit Lachover-Roth8,
  22. Vivien Béziat9,10,
  23. Anne Puel9,10,11,
  24. Jean-Laurent Casanova9,10,11,12,13,
  25. Bernhard Fleckenstein14,
  26. Stephan Weidinger15,
  27. Sara S. Kilic16,,
  28. Ben-Zion Garty6,17,,
  29. Amos Etzioni18, and
  30. Bodo Grimbacher1,19,20,,§
  1. 1Center for Chronic Immunodeficiency, Medical Center University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.
  2. 2Primary Immunodeficiency Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.
  3. 3Department of Hematology, Oncology and Stem Cell Transplantation, Medical Center University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.
  4. 4Department of Pediatrics, Hillel Yaffe Medical Center, Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
  5. 5National Center for Biotechnology Information, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20894, USA.
  6. 6Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
  7. 7Felsenstein Medical Research Center, Rabin Medical Center, Petah Tikva, Israel.
  8. 8Allergy and Immunology Clinic, Meir Medical Center, Kfar Saba, Israel.
  9. 9Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, 75015 Paris, France.
  10. 10Paris Descartes University, Imagine Institute, 75015 Paris, France.
  11. 11St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065, USA.
  12. 12Pediatric Hematology–Immunology Unit, Necker Hospital for Sick Children, Assistance Publique des Hôpitaux de Paris, 75015 Paris, France.
  13. 13Howard Hughes Medical Institute, New York, NY 10065, USA.
  14. 14Institute of Clinical and Molecular Virology, University of Erlangen-Nürnberg, Erlangen, Germany.
  15. 15Department of Dermatology, Venereology and Allergology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.
  16. 16Department of Pediatric Immunology, Uludag University Medical Faculty, Gorukle-Bursa, Turkey.
  17. 17Allergy and Immunology Clinic, Schneider Children’s Medical Center, Tel Aviv, Israel.
  18. 18Ruth’s Children Hospital, Rambam Health Care Campus and Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
  19. 19Institute of Immunology and Transplantation, Royal Free Hospital and University College London, London, UK.
  20. 20DZIF (German Center for Infection Research) Satellite Center Freiburg, Germany.
  1. §Corresponding author. Email: bodo.grimbacher{at}
  1. * These authors contributed equally to this work.

  • Present address: Department of Cardiology and Pulmonology, Brandenburg Medical School, University Hospital Brandenburg, Brandenburg a. d. Havel, Germany.

  • These authors contributed equally to this work.


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