Resident T cells stand up to HIV

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Science Immunology  01 Jun 2018:
Vol. 3, Issue 24, eaat6121
DOI: 10.1126/sciimmunol.aat6121


  • Fig. 1 Model showing the potential role of HIV-specific TRMs in natural control of HIV.

    Circulating HIV-specific CD8+ T cells move between blood and LTs via the afferent and efferent lymph. HIV-specific CD8+ T cells expressing CD69 are more frequent in LTs than in blood and efferent lymph and have signatures associated with TRMs. Within LT, HIV-specific TRMs, as defined by CD69 expression, are more abundant and exhibit more cytolytic properties than those of their CD69 counterparts. The spatial distribution of HIV-specific TRMs in the LN is not clear, but bulk CD8+ TRMs were found to be partially excluded from the follicles where HIV replication predominantly occurs. The study by Buggert et al. suggests that HIV-specific CD8+ TRMs are more abundant in ECs (right) than in chronic progressors (left), suggesting a role for TRMs in natural control of HIV.


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