Contents
July 2018
Vol 3, Issue 25
Vol 3, Issue 25
Editorials
- Celebrating twoness at Science Immunology
Science Immunology’s second anniversary invites a pause for editorial reflections.
- If we build it, they will come
Our author-centric approach to publishing your research.
Reviews
- Revisiting IL-2: Biology and therapeutic prospects
Deeper insights into the biology of interleukin-2 and its receptors are leading to therapeutic strategies for selective Treg stimulation.
- Type 2 immunity: Expanding our view
This Review focuses on our evolving view of type 2 immunity that has been spurred in recent years by the discovery of group 2 innate lymphoid cells.
Research Articles
- TCR signal strength controls the differentiation of CD4+ effector and memory T cells
Strong TCR signals favor the differentiation of short-lived effector TH1 cells over long-lived memory T cells.
- MR1 displays the microbial metabolome driving selective MR1-restricted T cell receptor usage
A diverse array of microbial metabolites binds to MR1 and selectively activates MR1-restricted T cells.
- Metabolic signaling directs the reciprocal lineage decisions of αβ and γδ T cells
Development of αβ and γδ T cells requires coupling of environmental signals with metabolic and redox regulation by mTORC1.
Editors' Choice
- Macrophages that fix or break the heart
Human myocardium contains different types of macrophages with heterogenous functions and origins.
- cROSs-presentation in pDCs: An energetic (m)CAT and mouse game
pDC cross-presentation of antigens to CD8+ T cells depends on mitochondrial generation of reactive oxygen species.
About The Cover
ONLINE COVER Binary Decision. Featured on the cover is a photograph of two of the moai statues located on Rapa Nui (Easter Island), a Polynesian island where a Streptomyces bacterial strain was isolated that yielded the macrolide drug rapamycin. Yang et al. report that commitment of T cell precursors to the αβ T cell lineage is compromised in mice with perturbed metabolic signaling caused by absence of the RAPTOR protein, an essential component of the mechanistic target of rapamycin complex 1 (mTORC1). The number two is the organizing theme of this second anniversary issue. [CREDIT: iStock.com/AlbertoLoyo]