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Neutrophil cytoplasts induce TH17 differentiation and skew inflammation toward neutrophilia in severe asthma

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Science Immunology  03 Aug 2018:
Vol. 3, Issue 26, eaao4747
DOI: 10.1126/sciimmunol.aao4747

Article Information

vol. 3 no. 26

Published By: 
  • Received July 25, 2017
  • Revision received March 9, 2018
  • Accepted July 5, 2018

Author Information

  1. Nandini Krishnamoorthy1,*,
  2. David N. Douda1,*,,
  3. Thayse R. Brüggemann1,
  4. Isabell Ricklefs1,
  5. Melody G. Duvall1,,
  6. Raja-Elie E. Abdulnour1,
  7. Kimberly Martinod2,§,
  8. Luciana Tavares1,
  9. Xiao Wang3,
  10. Manuela Cernadas1,,
  11. Elliot Israel1,
  12. David T. Mauger4,
  13. Eugene R. Bleecker5,
  14. Mario Castro6,
  15. Serpil C. Erzurum7,
  16. Benjamin M. Gaston8,
  17. Nizar N. Jarjour9,
  18. Sally Wenzel10,
  19. Eleanor Dunican11,,
  20. John V. Fahy11,
  21. Daniel Irimia3,
  22. Denisa D. Wagner2,
  23. Bruce D. Levy1,,
  24. National Heart, Lung, and Blood Institute Severe Asthma Research Program-3 Investigators
  1. 1Pulmonary and Critical Care Medicine Division, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA.
  2. 2Program in Cellular and Molecular Medicine, Division of Hematology and Oncology, Boston Children’s Hospital, Boston, MA 02115, USA.
  3. 3BioMEMS Resource Center, Massachusetts General Hospital, Harvard Medical School, MA 02129, USA.
  4. 4Division of Statistics and Bioinformatics, Department of Public Health Sciences, Pennsylvania State University, Hershey, PA 17033, USA.
  5. 5Center for Genomics and Personalized Medicine Research, School of Medicine, Wake Forest University, Winston-Salem, NC 27157, USA.
  6. 6Division of Pulmonary and Critical Care Medicine, Departments of Medicine and Pediatrics, Washington University, St. Louis, MO 63110, USA.
  7. 7Department of Pathobiology, Cleveland Clinic, Cleveland, OH 44195, USA.
  8. 8Department of Pediatrics, Rainbow Babies and Children’s Hospital, Case Western Reserve University, Cleveland, OH 44106, USA.
  9. 9Section of Pulmonary and Critical Care Medicine, University of Wisconsin School of Medicine, Madison, WI 53792, USA.
  10. 10Pulmonary, Allergy, and Critical Care Medicine Division, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
  11. 11Division of Pulmonary and Critical Care Medicine, Department of Medicine and the Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94143, USA.
  1. Corresponding author. Email: blevy{at}
  1. * These authors contributed equally to the work.

  • Present address: Zymeworks, Inc., Vancouver, Canada.

  • Present address: Boston Children’s Hospital, Boston, MA 02115, USA.

  • § Present address: Laboratory for Thrombosis Research, KU Leuven Campus Kulak Kortrijk, Kortrijk, Belgium.

  • Present address: School of Medicine, St Vincent’s Hospital, University College Dublin, Dublin, Ireland.


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