Research ArticleLYMPHATICS

Fibroblastic reticular cells initiate immune responses in visceral adipose tissues and secure peritoneal immunity

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Science Immunology  10 Aug 2018:
Vol. 3, Issue 26, eaar4539
DOI: 10.1126/sciimmunol.aar4539

Setting the stage for attack

In classical secondary lymphoid organs (SLOs) such as lymph nodes, tonsils, and Peyer’s patches, it is well established that fibroblastic reticular cells (FRCs) play an integral role in the generation of immune responses. Nonclassical SLOs, including fat-associated lymphoid clusters (FALCs), also play important roles in systemic immunity. However, the role of FRCs in FALCs has not been previously examined. Here, using Ccl19-driven cre to delete MYD88 in FALC-associated FRCs, Perez-Shibayama et al. report that FRCs in FALCs play both organizational and immunomodulatory roles. These studies add to the growing recognition of the importance of stromal cells in shaping immune organs and immune responses.

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