Research ArticleCELL DEATH

Noncanonical inflammasome signaling elicits gasdermin D–dependent neutrophil extracellular traps

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Science Immunology  24 Aug 2018:
Vol. 3, Issue 26, eaar6676
DOI: 10.1126/sciimmunol.aar6676

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  • RE: Noncanonical inflammasome signaling elicits gasdermin D–dependent neutrophil extracellular traps
    • Dianne Sika-Paotonu, Associate Dean (Pacific)/Senior Lecturer Pathology & Molecular Medicine, Wellington School of Medicine & Health Sciences, University of Otago, New Zealand

    To the Editor,

    I read with interest the article published by Chen K. W., et al. (1) and entitled: “Non canonical inflammasome signalling elicits gasdermin D-dependent neutrophil extracellular traps.”

    This work explored a nonclassical host defense mechanism for neutralizing extracellular pathogens, involving neutrophil extrusion of neutrophil extracellular traps (NETs) and concomitant cell death (NETosis). NETs are DNA structures containing antimicrobial proteins that ensnare and neutralize microbes.

    Upon investigating neutrophil mediated host defense mechanisms against bacterial invasion, it was demonstrated that neutrophil cytosolic LPS or cytosolic Gram-negative bacteria could activate noncanonical (caspase-4/11) inflammasome signalling, and trigger gasdermin D (GSDMD)-dependent neutrophil death along with the extrusion of NETs.

    It was also reported that Caspase-11 and GSDMD were both required for neutrophil plasma membrane rupture during NET extrusion, and also for early NETosis within the context of host defense against extracellular pathogens.

    An unexpected discovery that was also described involved GSDMD (– also referred to as the executioner protein) as being a mediator for neutrophil extrusion of NETs and the concomitant NETosis against extracellular pathogens, in addition, to mediating macrophage death by pyroptosis for defense against intracellular pathogens.

    This work overall demonstrated the use of an inflammasome-a...

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    Competing Interests: None declared.