Research ArticleCELL DEATH

Chemical disruption of the pyroptotic pore-forming protein gasdermin D inhibits inflammatory cell death and sepsis

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Science Immunology  24 Aug 2018:
Vol. 3, Issue 26, eaat2738
DOI: 10.1126/sciimmunol.aat2738

Article Information

vol. 3 no. 26

PubMed: 
Published By: 
History: 
  • Received February 9, 2018
  • Revision received May 8, 2018
  • Accepted June 28, 2018
  • .

Author Information

  1. Joseph K. Rathkey1,
  2. Junjie Zhao2,
  3. Zhonghua Liu1,
  4. Yinghua Chen3,
  5. Jie Yang1,3,
  6. Hannah C. Kondolf1,
  7. Bryan L. Benson1,
  8. Steven M. Chirieleison1,
  9. Alex Y. Huang1,4,
  10. George R. Dubyak3,
  11. Tsan S. Xiao1,
  12. Xiaoxia Li2 and
  13. Derek W. Abbott1,*
  1. 1Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
  2. 2Department of Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
  3. 3Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
  4. 4Division of Pediatric Hematology-Oncology, Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
  1. *Corresponding author. Email: dwa4{at}case.edu

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