Research ArticleCELL DEATH
Chemical disruption of the pyroptotic pore-forming protein gasdermin D inhibits inflammatory cell death and sepsis
- Joseph K. Rathkey1,
- Junjie Zhao2,
- Zhonghua Liu1,
- View ORCID ProfileYinghua Chen3,
- Jie Yang1,3,
- View ORCID ProfileHannah C. Kondolf1,
- View ORCID ProfileBryan L. Benson1,
- View ORCID ProfileSteven M. Chirieleison1,
- View ORCID ProfileAlex Y. Huang1,4,
- View ORCID ProfileGeorge R. Dubyak3,
- View ORCID ProfileTsan S. Xiao1,
- View ORCID ProfileXiaoxia Li2 and
- View ORCID ProfileDerek W. Abbott1,*
- 1Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
- 2Department of Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
- 3Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
- 4Division of Pediatric Hematology-Oncology, Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
- ↵*Corresponding author. Email: dwa4{at}case.edu
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Science Immunology 24 Aug 2018:
Vol. 3, Issue 26, eaat2738
DOI: 10.1126/sciimmunol.aat2738
Vol. 3, Issue 26, eaat2738
DOI: 10.1126/sciimmunol.aat2738
Joseph K. Rathkey
1Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Junjie Zhao
2Department of Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
Zhonghua Liu
1Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Yinghua Chen
3Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Jie Yang
1Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
3Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Hannah C. Kondolf
1Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Bryan L. Benson
1Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Steven M. Chirieleison
1Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Alex Y. Huang
1Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
4Division of Pediatric Hematology-Oncology, Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
George R. Dubyak
3Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Tsan S. Xiao
1Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Xiaoxia Li
2Department of Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
Derek W. Abbott
1Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
