Research ArticleCELL DEATH
Chemical disruption of the pyroptotic pore-forming protein gasdermin D inhibits inflammatory cell death and sepsis
- Joseph K. Rathkey1,
- Junjie Zhao2,
- Zhonghua Liu1,
- Yinghua Chen3,
- Jie Yang1,3,
- Hannah C. Kondolf1,
- Bryan L. Benson1,
- Steven M. Chirieleison1,
- Alex Y. Huang1,4,
- George R. Dubyak3,
- Tsan S. Xiao1,
- Xiaoxia Li2 and
- Derek W. Abbott1,*
- 1Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
- 2Department of Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
- 3Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
- 4Division of Pediatric Hematology-Oncology, Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
- ↵*Corresponding author. Email: dwa4{at}case.edu
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Science Immunology 24 Aug 2018:
Vol. 3, Issue 26, eaat2738
DOI: 10.1126/sciimmunol.aat2738
