Research ArticleCELL DEATH
Chemical disruption of the pyroptotic pore-forming protein gasdermin D inhibits inflammatory cell death and sepsis
- Joseph K. Rathkey1,
- Junjie Zhao2,
- Zhonghua Liu1,
- Yinghua Chen3,
- Jie Yang1,3,
- Hannah C. Kondolf1,
- Bryan L. Benson1,
- Steven M. Chirieleison1,
- Alex Y. Huang1,4,
- George R. Dubyak3,
- Tsan S. Xiao1,
- Xiaoxia Li2 and
- Derek W. Abbott1,*
- 1Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
- 2Department of Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
- 3Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
- 4Division of Pediatric Hematology-Oncology, Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
- ↵*Corresponding author. Email: dwa4{at}case.edu
See allHide authors and affiliations
Science Immunology 24 Aug 2018:
Vol. 3, Issue 26, eaat2738
DOI: 10.1126/sciimmunol.aat2738
Vol. 3, Issue 26, eaat2738
DOI: 10.1126/sciimmunol.aat2738
Joseph K. Rathkey
Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Junjie Zhao
Department of Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
Zhonghua Liu
Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Yinghua Chen
Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Jie Yang
Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Hannah C. Kondolf
Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Bryan L. Benson
Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Steven M. Chirieleison
Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Alex Y. Huang
Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.Division of Pediatric Hematology-Oncology, Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
George R. Dubyak
Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Tsan S. Xiao
Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Xiaoxia Li
Department of Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
Derek W. Abbott
Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
