Research ArticleINFECTIOUS DISEASES
Human antimicrobial cytotoxic T lymphocytes, defined by NK receptors and antimicrobial proteins, kill intracellular bacteria
- Samuel J. Balin1,2,
- Matteo Pellegrini3,
- Eynav Klechevsky4,
- Sohui T. Won2,
- David I. Weiss5,
- Aaron W. Choi2,
- Joshua Hakimian2,
- Jing Lu3,
- Maria Teresa Ochoa6,
- Barry R. Bloom7,
- Lewis L. Lanier8,
- Steffen Stenger9 and
- Robert L. Modlin1,2,*
- 1Division of Dermatology, Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA.
- 2Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
- 3Molecular Cell and Developmental Biology at UCLA, Los Angeles, CA 90095, USA.
- 4Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63108, USA.
- 5Molecular Biology Interdepartmental Graduate Program, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
- 6Department of Dermatology, University of Southern California School of Medicine, Los Angeles, CA 90033, USA.
- 7Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
- 8Department of Microbiology and Immunology and the Parker Institute for Cancer Immunotherapy, University of California, San Francisco, San Francisco, CA 94143, USA.
- 9Institute for Medical Microbiology and Hygiene, University Hospital Ulm, Ulm, Germany.
- ↵*Corresponding author. Email: rmodlin{at}mednet.ucla.edu
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Science Immunology 31 Aug 2018:
Vol. 3, Issue 26, eaat7668
DOI: 10.1126/sciimmunol.aat7668
Vol. 3, Issue 26, eaat7668
DOI: 10.1126/sciimmunol.aat7668
Samuel J. Balin
Division of Dermatology, Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA.Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
Matteo Pellegrini
Molecular Cell and Developmental Biology at UCLA, Los Angeles, CA 90095, USA.
Eynav Klechevsky
Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63108, USA.
Sohui T. Won
Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
David I. Weiss
Molecular Biology Interdepartmental Graduate Program, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
Aaron W. Choi
Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
Joshua Hakimian
Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
Jing Lu
Molecular Cell and Developmental Biology at UCLA, Los Angeles, CA 90095, USA.
Maria Teresa Ochoa
Department of Dermatology, University of Southern California School of Medicine, Los Angeles, CA 90033, USA.
Barry R. Bloom
Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Lewis L. Lanier
Department of Microbiology and Immunology and the Parker Institute for Cancer Immunotherapy, University of California, San Francisco, San Francisco, CA 94143, USA.
Steffen Stenger
Institute for Medical Microbiology and Hygiene, University Hospital Ulm, Ulm, Germany.
Robert L. Modlin
Division of Dermatology, Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA.Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
