Research ArticleINFECTIOUS DISEASES
Human antimicrobial cytotoxic T lymphocytes, defined by NK receptors and antimicrobial proteins, kill intracellular bacteria
- View ORCID ProfileSamuel J. Balin1,2,
- View ORCID ProfileMatteo Pellegrini3,
- View ORCID ProfileEynav Klechevsky4,
- Sohui T. Won2,
- View ORCID ProfileDavid I. Weiss5,
- Aaron W. Choi2,
- Joshua Hakimian2,
- Jing Lu3,
- View ORCID ProfileMaria Teresa Ochoa6,
- Barry R. Bloom7,
- View ORCID ProfileLewis L. Lanier8,
- Steffen Stenger9 and
- View ORCID ProfileRobert L. Modlin1,2,*
- 1Division of Dermatology, Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA.
- 2Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
- 3Molecular Cell and Developmental Biology at UCLA, Los Angeles, CA 90095, USA.
- 4Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63108, USA.
- 5Molecular Biology Interdepartmental Graduate Program, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
- 6Department of Dermatology, University of Southern California School of Medicine, Los Angeles, CA 90033, USA.
- 7Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
- 8Department of Microbiology and Immunology and the Parker Institute for Cancer Immunotherapy, University of California, San Francisco, San Francisco, CA 94143, USA.
- 9Institute for Medical Microbiology and Hygiene, University Hospital Ulm, Ulm, Germany.
- ↵*Corresponding author. Email: rmodlin{at}mednet.ucla.edu
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Science Immunology 31 Aug 2018:
Vol. 3, Issue 26, eaat7668
DOI: 10.1126/sciimmunol.aat7668
Vol. 3, Issue 26, eaat7668
DOI: 10.1126/sciimmunol.aat7668
Samuel J. Balin
1Division of Dermatology, Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA.
2Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
Matteo Pellegrini
3Molecular Cell and Developmental Biology at UCLA, Los Angeles, CA 90095, USA.
Eynav Klechevsky
4Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63108, USA.
Sohui T. Won
2Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
David I. Weiss
5Molecular Biology Interdepartmental Graduate Program, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
Aaron W. Choi
2Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
Joshua Hakimian
2Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
Jing Lu
3Molecular Cell and Developmental Biology at UCLA, Los Angeles, CA 90095, USA.
Maria Teresa Ochoa
6Department of Dermatology, University of Southern California School of Medicine, Los Angeles, CA 90033, USA.
Barry R. Bloom
7Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Lewis L. Lanier
8Department of Microbiology and Immunology and the Parker Institute for Cancer Immunotherapy, University of California, San Francisco, San Francisco, CA 94143, USA.
Steffen Stenger
9Institute for Medical Microbiology and Hygiene, University Hospital Ulm, Ulm, Germany.
Robert L. Modlin
1Division of Dermatology, Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA.
2Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
