Research ArticleALLERGY
Inception of early-life allergen–induced airway hyperresponsiveness is reliant on IL-13+CD4+ T cells
- View ORCID ProfileSejal Saglani1,2,*,
- Lisa G. Gregory1,
- Avneet K. Manghera1,
- View ORCID ProfileWilliam J. Branchett1,
- View ORCID ProfileFaith Uwadiae1,
- View ORCID ProfileLewis J. Entwistle1,
- R. A. Oliver1,
- View ORCID ProfileJessica E. Vasiliou1,
- View ORCID ProfileRebekah Sherburn1,
- Stephen Lui1,
- F. Puttur1,
- View ORCID ProfileDavid Vöhringer3,
- Simone A. Walker1,
- View ORCID ProfileJames Buckley1,
- Ruth Grychtol1,
- View ORCID ProfileValentina Fainardi1,
- Laura Denney1,
- Adam Byrne1,
- View ORCID ProfileErika von Mutius4,
- View ORCID ProfileAndrew Bush2 and
- View ORCID ProfileClare M. Lloyd1,*
- 1Inflammation, Repair and Development, National Heart and Lung Institute, Imperial College London, London, UK.
- 2Respiratory Paediatrics, Royal Brompton Hospital and National Heart and Lung Institute, Imperial College London, London, UK.
- 3Universitätsklinikum Erlangen, Friedrich-Alexander Universität Erlangen-Nürnberg Wasserturmstrasse 3-5, 91054 Erlangen, Germany.
- 4Dr Von Hauner Childrens Hospital of Ludwig-Maximilians-Universitaet of Munich and Helmholtz Zentrum Munchen–German Research Center for Environmental Health, Institute for Asthma and Allergy Prevention, Ingolstaedter Landstrasse 1, 85764 Neuherberg, Germany.
- ↵*Corresponding author. Email: c.lloyd{at}imperial.ac.uk (C.M.L.); s.saglani{at}imperial.ac.uk (S.S.)
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Science Immunology 07 Sep 2018:
Vol. 3, Issue 27, eaan4128
DOI: 10.1126/sciimmunol.aan4128
Vol. 3, Issue 27, eaan4128
DOI: 10.1126/sciimmunol.aan4128
Sejal Saglani
1Inflammation, Repair and Development, National Heart and Lung Institute, Imperial College London, London, UK.
2Respiratory Paediatrics, Royal Brompton Hospital and National Heart and Lung Institute, Imperial College London, London, UK.
Lisa G. Gregory
1Inflammation, Repair and Development, National Heart and Lung Institute, Imperial College London, London, UK.
Avneet K. Manghera
1Inflammation, Repair and Development, National Heart and Lung Institute, Imperial College London, London, UK.
William J. Branchett
1Inflammation, Repair and Development, National Heart and Lung Institute, Imperial College London, London, UK.
Faith Uwadiae
1Inflammation, Repair and Development, National Heart and Lung Institute, Imperial College London, London, UK.
Lewis J. Entwistle
1Inflammation, Repair and Development, National Heart and Lung Institute, Imperial College London, London, UK.
R. A. Oliver
1Inflammation, Repair and Development, National Heart and Lung Institute, Imperial College London, London, UK.
Jessica E. Vasiliou
1Inflammation, Repair and Development, National Heart and Lung Institute, Imperial College London, London, UK.
Rebekah Sherburn
1Inflammation, Repair and Development, National Heart and Lung Institute, Imperial College London, London, UK.
Stephen Lui
1Inflammation, Repair and Development, National Heart and Lung Institute, Imperial College London, London, UK.
F. Puttur
1Inflammation, Repair and Development, National Heart and Lung Institute, Imperial College London, London, UK.
David Vöhringer
3Universitätsklinikum Erlangen, Friedrich-Alexander Universität Erlangen-Nürnberg Wasserturmstrasse 3-5, 91054 Erlangen, Germany.
Simone A. Walker
1Inflammation, Repair and Development, National Heart and Lung Institute, Imperial College London, London, UK.
James Buckley
1Inflammation, Repair and Development, National Heart and Lung Institute, Imperial College London, London, UK.
Ruth Grychtol
1Inflammation, Repair and Development, National Heart and Lung Institute, Imperial College London, London, UK.
Valentina Fainardi
1Inflammation, Repair and Development, National Heart and Lung Institute, Imperial College London, London, UK.
Laura Denney
1Inflammation, Repair and Development, National Heart and Lung Institute, Imperial College London, London, UK.
Adam Byrne
1Inflammation, Repair and Development, National Heart and Lung Institute, Imperial College London, London, UK.
Erika von Mutius
4Dr Von Hauner Childrens Hospital of Ludwig-Maximilians-Universitaet of Munich and Helmholtz Zentrum Munchen–German Research Center for Environmental Health, Institute for Asthma and Allergy Prevention, Ingolstaedter Landstrasse 1, 85764 Neuherberg, Germany.
Andrew Bush
2Respiratory Paediatrics, Royal Brompton Hospital and National Heart and Lung Institute, Imperial College London, London, UK.
Clare M. Lloyd
1Inflammation, Repair and Development, National Heart and Lung Institute, Imperial College London, London, UK.
