Inception of early-life allergen–induced airway hyperresponsiveness is reliant on IL-13+CD4+ T cells

Sejal Saglani; Lisa G. Gregory; Avneet K. Manghera; William J. Branchett; Faith Uwadiae; Lewis J. Entwistle; R. A. Oliver; Jessica E. Vasiliou; Rebekah Sherburn; Stephen Lui; F. Puttur; David Vöhringer; Simone A. Walker; James Buckley; Ruth Grychtol; Valentina Fainardi; Laura Denney; Adam Byrne; Erika von Mutius; Andrew Bush; Clare M. Lloyd

doi:10.1126/sciimmunol.aan4128

Research ArticleALLERGY

Inception of early-life allergen–induced airway hyperresponsiveness is reliant on IL-13⁺CD4⁺ T cells

Sejal Saglani ¹,²,*,
Lisa G. Gregory¹,
Avneet K. Manghera¹,
William J. Branchett¹,
Faith Uwadiae¹,
Lewis J. Entwistle¹,
R. A. Oliver¹,
Jessica E. Vasiliou¹,
Rebekah Sherburn¹,
Stephen Lui¹,
F. Puttur¹,
David Vöhringer³,
Simone A. Walker¹,
James Buckley¹,
Ruth Grychtol¹,
Valentina Fainardi¹,
Laura Denney¹,
Adam Byrne¹,
Erika von Mutius⁴,
Andrew Bush² and
Clare M. Lloyd ¹,*

¹Inflammation, Repair and Development, National Heart and Lung Institute, Imperial College London, London, UK.
²Respiratory Paediatrics, Royal Brompton Hospital and National Heart and Lung Institute, Imperial College London, London, UK.
³Universitätsklinikum Erlangen, Friedrich-Alexander Universität Erlangen-Nürnberg Wasserturmstrasse 3-5, 91054 Erlangen, Germany.
⁴Dr Von Hauner Childrens Hospital of Ludwig-Maximilians-Universitaet of Munich and Helmholtz Zentrum Munchen–German Research Center for Environmental Health, Institute for Asthma and Allergy Prevention, Ingolstaedter Landstrasse 1, 85764 Neuherberg, Germany.

↵*Corresponding author. Email: c.lloyd{at}imperial.ac.uk (C.M.L.); s.saglani{at}imperial.ac.uk (S.S.)

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Science Immunology 07 Sep 2018:
Vol. 3, Issue 27, eaan4128
DOI: 10.1126/sciimmunol.aan4128

Sejal Saglani

Inflammation, Repair and Development, National Heart and Lung Institute, Imperial College London, London, UK.Respiratory Paediatrics, Royal Brompton Hospital and National Heart and Lung Institute, Imperial College London, London, UK.

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For correspondence: c.lloyd@imperial.ac.uk s.saglani@imperial.ac.uk

Lisa G. Gregory

Inflammation, Repair and Development, National Heart and Lung Institute, Imperial College London, London, UK.

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Avneet K. Manghera

Inflammation, Repair and Development, National Heart and Lung Institute, Imperial College London, London, UK.

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William J. Branchett

Inflammation, Repair and Development, National Heart and Lung Institute, Imperial College London, London, UK.

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Faith Uwadiae

Inflammation, Repair and Development, National Heart and Lung Institute, Imperial College London, London, UK.

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Lewis J. Entwistle

Inflammation, Repair and Development, National Heart and Lung Institute, Imperial College London, London, UK.

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R. A. Oliver

Inflammation, Repair and Development, National Heart and Lung Institute, Imperial College London, London, UK.

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Jessica E. Vasiliou

Inflammation, Repair and Development, National Heart and Lung Institute, Imperial College London, London, UK.

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Rebekah Sherburn

Inflammation, Repair and Development, National Heart and Lung Institute, Imperial College London, London, UK.

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Stephen Lui

Inflammation, Repair and Development, National Heart and Lung Institute, Imperial College London, London, UK.

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F. Puttur

Inflammation, Repair and Development, National Heart and Lung Institute, Imperial College London, London, UK.

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David Vöhringer

Universitätsklinikum Erlangen, Friedrich-Alexander Universität Erlangen-Nürnberg Wasserturmstrasse 3-5, 91054 Erlangen, Germany.

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Simone A. Walker

Inflammation, Repair and Development, National Heart and Lung Institute, Imperial College London, London, UK.

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James Buckley

Inflammation, Repair and Development, National Heart and Lung Institute, Imperial College London, London, UK.

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Ruth Grychtol

Inflammation, Repair and Development, National Heart and Lung Institute, Imperial College London, London, UK.

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Valentina Fainardi

Inflammation, Repair and Development, National Heart and Lung Institute, Imperial College London, London, UK.

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Laura Denney

Inflammation, Repair and Development, National Heart and Lung Institute, Imperial College London, London, UK.

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Adam Byrne

Inflammation, Repair and Development, National Heart and Lung Institute, Imperial College London, London, UK.

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Erika von Mutius

Dr Von Hauner Childrens Hospital of Ludwig-Maximilians-Universitaet of Munich and Helmholtz Zentrum Munchen–German Research Center for Environmental Health, Institute for Asthma and Allergy Prevention, Ingolstaedter Landstrasse 1, 85764 Neuherberg, Germany.

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Andrew Bush

Respiratory Paediatrics, Royal Brompton Hospital and National Heart and Lung Institute, Imperial College London, London, UK.

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Clare M. Lloyd

Inflammation, Repair and Development, National Heart and Lung Institute, Imperial College London, London, UK.

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For correspondence: c.lloyd@imperial.ac.uk s.saglani@imperial.ac.uk

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Inception of early-life allergen–induced airway hyperresponsiveness is reliant on IL-13⁺CD4⁺ T cells

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