Research ArticleALLERGY
Inception of early-life allergen–induced airway hyperresponsiveness is reliant on IL-13+CD4+ T cells
- Sejal Saglani1,2,*,
- Lisa G. Gregory1,
- Avneet K. Manghera1,
- William J. Branchett1,
- Faith Uwadiae1,
- Lewis J. Entwistle1,
- R. A. Oliver1,
- Jessica E. Vasiliou1,
- Rebekah Sherburn1,
- Stephen Lui1,
- F. Puttur1,
- David Vöhringer3,
- Simone A. Walker1,
- James Buckley1,
- Ruth Grychtol1,
- Valentina Fainardi1,
- Laura Denney1,
- Adam Byrne1,
- Erika von Mutius4,
- Andrew Bush2 and
- Clare M. Lloyd1,*
- 1Inflammation, Repair and Development, National Heart and Lung Institute, Imperial College London, London, UK.
- 2Respiratory Paediatrics, Royal Brompton Hospital and National Heart and Lung Institute, Imperial College London, London, UK.
- 3Universitätsklinikum Erlangen, Friedrich-Alexander Universität Erlangen-Nürnberg Wasserturmstrasse 3-5, 91054 Erlangen, Germany.
- 4Dr Von Hauner Childrens Hospital of Ludwig-Maximilians-Universitaet of Munich and Helmholtz Zentrum Munchen–German Research Center for Environmental Health, Institute for Asthma and Allergy Prevention, Ingolstaedter Landstrasse 1, 85764 Neuherberg, Germany.
- ↵*Corresponding author. Email: c.lloyd{at}imperial.ac.uk (C.M.L.); s.saglani{at}imperial.ac.uk (S.S.)
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Science Immunology 07 Sep 2018:
Vol. 3, Issue 27, eaan4128
DOI: 10.1126/sciimmunol.aan4128
Vol. 3, Issue 27, eaan4128
DOI: 10.1126/sciimmunol.aan4128
Sejal Saglani
Inflammation, Repair and Development, National Heart and Lung Institute, Imperial College London, London, UK.Respiratory Paediatrics, Royal Brompton Hospital and National Heart and Lung Institute, Imperial College London, London, UK.
Lisa G. Gregory
Inflammation, Repair and Development, National Heart and Lung Institute, Imperial College London, London, UK.
Avneet K. Manghera
Inflammation, Repair and Development, National Heart and Lung Institute, Imperial College London, London, UK.
William J. Branchett
Inflammation, Repair and Development, National Heart and Lung Institute, Imperial College London, London, UK.
Faith Uwadiae
Inflammation, Repair and Development, National Heart and Lung Institute, Imperial College London, London, UK.
Lewis J. Entwistle
Inflammation, Repair and Development, National Heart and Lung Institute, Imperial College London, London, UK.
R. A. Oliver
Inflammation, Repair and Development, National Heart and Lung Institute, Imperial College London, London, UK.
Jessica E. Vasiliou
Inflammation, Repair and Development, National Heart and Lung Institute, Imperial College London, London, UK.
Rebekah Sherburn
Inflammation, Repair and Development, National Heart and Lung Institute, Imperial College London, London, UK.
Stephen Lui
Inflammation, Repair and Development, National Heart and Lung Institute, Imperial College London, London, UK.
F. Puttur
Inflammation, Repair and Development, National Heart and Lung Institute, Imperial College London, London, UK.
David Vöhringer
Universitätsklinikum Erlangen, Friedrich-Alexander Universität Erlangen-Nürnberg Wasserturmstrasse 3-5, 91054 Erlangen, Germany.
Simone A. Walker
Inflammation, Repair and Development, National Heart and Lung Institute, Imperial College London, London, UK.
James Buckley
Inflammation, Repair and Development, National Heart and Lung Institute, Imperial College London, London, UK.
Ruth Grychtol
Inflammation, Repair and Development, National Heart and Lung Institute, Imperial College London, London, UK.
Valentina Fainardi
Inflammation, Repair and Development, National Heart and Lung Institute, Imperial College London, London, UK.
Laura Denney
Inflammation, Repair and Development, National Heart and Lung Institute, Imperial College London, London, UK.
Adam Byrne
Inflammation, Repair and Development, National Heart and Lung Institute, Imperial College London, London, UK.
Erika von Mutius
Dr Von Hauner Childrens Hospital of Ludwig-Maximilians-Universitaet of Munich and Helmholtz Zentrum Munchen–German Research Center for Environmental Health, Institute for Asthma and Allergy Prevention, Ingolstaedter Landstrasse 1, 85764 Neuherberg, Germany.
Andrew Bush
Respiratory Paediatrics, Royal Brompton Hospital and National Heart and Lung Institute, Imperial College London, London, UK.
Clare M. Lloyd
Inflammation, Repair and Development, National Heart and Lung Institute, Imperial College London, London, UK.
