Contents
October 2018
Vol 3, Issue 28
Vol 3, Issue 28
Focus
- Glycans for good
The gut commensal bacterium Bifidobacterium bifidum promotes immune tolerance by facilitating the induction of colonic regulatory T cells. See related Research Article by Verma et al.
- Airway brush cells: Not as “tuft” as you might think
CysLT3R regulates expansion of chemosensory brush cells and production of IL-25 in the airways. See related Research Article by Bankova et al.
Research Articles
- Type 3 cytokines IL-17A and IL-22 drive TGF-β–dependent liver fibrosis
Type 3 immune response defined by increased IL-22 production drives fibrosis during chronic liver injury via enhanced TGF-β signaling.
- Cell surface polysaccharides of Bifidobacterium bifidum induce the generation of Foxp3+ regulatory T cells
Cell wall components of probiotic bacterium Bifidobacterium bifidum drive induction of regulatory T cells in the gut.
- A subset of HLA-I peptides are not genomically templated: Evidence for cis- and trans-spliced peptide ligands
A considerable proportion of HLA-I peptides likely derive from cis- and trans-splicing events.
- The cysteinyl leukotriene 3 receptor regulates expansion of IL-25–producing airway brush cells leading to type 2 inflammation
The leukotriene E4 receptor, CysLT3R, regulates allergen-elicited expansion of airway brush cells and type 2 inflammation.
- Emergence of immunoregulatory Ym1+Ly6Chi monocytes during recovery phase of tissue injury
Ym1+Ly6Chi monocytes arise in bone marrow during the recovery phase of inflammation and participate in tissue repair.
Editors' Choice
- Checking into the germinal centers: PD-1 regulates entry
PD-1 functions on T follicular helper cells to dictate localization within lymph node germinal centers.
- B cells drive auto-T cells to the brain
Self-reactive T cells that traffic to the brain tissue of patients with multiple sclerosis are driven by antigen-experienced B cells.
About The Cover
ONLINE COVER Brush Strokes. The cover features an immunofluorescence image showing three brush cells in mouse tracheal epithelium that co-express the chemosensory cell marker doublecortin-like kinase 1 (DCLK1; green) and the cytokine interleukin-25 (IL-25; red). Airway brush cells display a characteristic tuft of microvilli at their apical tip and express receptors also found in taste-sensing cells. Bankova et al. report that aeroallergen inhalation induces an increase in IL-25–producing brush cells that depends on the lipid mediator leukotriene E4 activating the cysteinyl leukotriene 3 receptor. [CREDIT: BANKOVA ET AL./SCIENCE IMMUNOLOGY]