A subset of HLA-I peptides are not genomically templated: Evidence for cis- and trans-spliced peptide ligands

Pouya Faridi; Chen Li; Sri H. Ramarathinam; Julian P. Vivian; Patricia T. Illing; Nicole A. Mifsud; Rochelle Ayala; Jiangning Song; Linden J. Gearing; Paul J. Hertzog; Nicola Ternette; Jamie Rossjohn; Nathan P. Croft; Anthony W. Purcell

doi:10.1126/sciimmunol.aar3947

Research ArticleANTIGEN PRESENTATION

A subset of HLA-I peptides are not genomically templated: Evidence for cis- and trans-spliced peptide ligands

View ORCID ProfilePouya Faridi¹,
View ORCID ProfileChen Li¹,²,
View ORCID ProfileSri H. Ramarathinam¹,
View ORCID ProfileJulian P. Vivian¹,³,
View ORCID ProfilePatricia T. Illing¹,
View ORCID ProfileNicole A. Mifsud¹,
View ORCID ProfileRochelle Ayala¹,
View ORCID ProfileJiangning Song ¹,⁴,
Linden J. Gearing⁵,
Paul J. Hertzog⁵,
View ORCID ProfileNicola Ternette⁶,
View ORCID ProfileJamie Rossjohn¹,³,⁷,
View ORCID ProfileNathan P. Croft ¹,* and
View ORCID ProfileAnthony W. Purcell¹,*

¹Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Australia.
²Department of Biology, Institute of Molecular Systems Biology,ETH Zurich, Zurich 8093, Switzerland.
³Australian Research Council Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, Victoria 3800, Australia.
⁴Monash Centre for Data Science, Faculty of Information Technology, Monash University, Melbourne, Victoria 3800, Australia.
⁵Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research and Department of Molecular and Translational Science, School of Clinical Science, Monash University, Clayton, Victoria 3168, Australia.
⁶Jenner Institute, University of Oxford, Oxford OX3 7FZ, UK.
⁷Institute of Infection and Immunity, Cardiff University School of Medicine,Heath Park, Cardiff CF14 4XN, UK.

↵*Corresponding author. Email: anthony.purcell{at}monash.edu (A.W.P.); nathan.croft{at}monash.edu (N.P.C.)

See allHide authors and affiliations

Science Immunology 12 Oct 2018:
Vol. 3, Issue 28, eaar3947
DOI: 10.1126/sciimmunol.aar3947

Pouya Faridi

1Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Australia.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Pouya Faridi

Chen Li

1Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Australia.

2Department of Biology, Institute of Molecular Systems Biology,ETH Zurich, Zurich 8093, Switzerland.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Chen Li

Sri H. Ramarathinam

1Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Australia.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Sri H. Ramarathinam

Julian P. Vivian

1Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Australia.

3Australian Research Council Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, Victoria 3800, Australia.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Julian P. Vivian

Patricia T. Illing

1Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Australia.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Patricia T. Illing

Nicole A. Mifsud

1Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Australia.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Nicole A. Mifsud

Rochelle Ayala

1Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Australia.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Rochelle Ayala

Jiangning Song

1Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Australia.

4Monash Centre for Data Science, Faculty of Information Technology, Monash University, Melbourne, Victoria 3800, Australia.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Jiangning Song

Linden J. Gearing

5Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research and Department of Molecular and Translational Science, School of Clinical Science, Monash University, Clayton, Victoria 3168, Australia.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Paul J. Hertzog

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Nicola Ternette

6Jenner Institute, University of Oxford, Oxford OX3 7FZ, UK.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Nicola Ternette

Jamie Rossjohn

1Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Australia.

3Australian Research Council Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, Victoria 3800, Australia.

7Institute of Infection and Immunity, Cardiff University School of Medicine,Heath Park, Cardiff CF14 4XN, UK.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Jamie Rossjohn

Nathan P. Croft

1Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Australia.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Nathan P. Croft
For correspondence: anthony.purcell@monash.edu nathan.croft@monash.edu

Anthony W. Purcell

1Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Australia.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Anthony W. Purcell
For correspondence: anthony.purcell@monash.edu nathan.croft@monash.edu

Article
Figures & Data
Info & Metrics
eLetters
PDF

eLetters is an online forum for ongoing peer review. Submission of eLetters are open to all. eLetters are not edited, proofread, or indexed. Please read our Terms of Service before submitting your own eLetter.

Submit a Response to This Article

Compose eLetter

Title

Contents

More information about text formats

Plain text

Plain text
No HTML tags allowed.
Web page addresses and e-mail addresses turn into links automatically.
Lines and paragraphs break automatically.

Author Information

Contributors
First name and middle name First or given name, e.g. 'Peter'. Last Name Your last, or family, name, e.g. 'MacMoody'. Email Your email address, e.g. higgs-boson@gmail.com Role / Occupation Your role and/or occupation, e.g. 'Orthopedic Surgeon'. Affiliation Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.

Statement of Competing Interests

Competing interests?

Yes

Please describe the competing interests

CAPTCHA

This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

Vertical Tabs

No eLetters have been published for this article.

View Full Text

A subset of HLA-I peptides are not genomically templated: Evidence for cis- and trans-spliced peptide ligands

Plain text

Vertical Tabs

Science Immunology

Article Tools