A subset of HLA-I peptides are not genomically templated: Evidence for cis- and trans-spliced peptide ligands

Pouya Faridi; Chen Li; Sri H. Ramarathinam; Julian P. Vivian; Patricia T. Illing; Nicole A. Mifsud; Rochelle Ayala; Jiangning Song; Linden J. Gearing; Paul J. Hertzog; Nicola Ternette; Jamie Rossjohn; Nathan P. Croft; Anthony W. Purcell

doi:10.1126/sciimmunol.aar3947

Research ArticleANTIGEN PRESENTATION

A subset of HLA-I peptides are not genomically templated: Evidence for cis- and trans-spliced peptide ligands

Pouya Faridi¹,
Chen Li¹,²,
Sri H. Ramarathinam¹,
Julian P. Vivian¹,³,
Patricia T. Illing¹,
Nicole A. Mifsud¹,
Rochelle Ayala¹,
Jiangning Song ¹,⁴,
Linden J. Gearing⁵,
Paul J. Hertzog⁵,
Nicola Ternette⁶,
Jamie Rossjohn¹,³,⁷,
Nathan P. Croft ¹,* and
Anthony W. Purcell¹,*

¹Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Australia.
²Department of Biology, Institute of Molecular Systems Biology,ETH Zurich, Zurich 8093, Switzerland.
³Australian Research Council Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, Victoria 3800, Australia.
⁴Monash Centre for Data Science, Faculty of Information Technology, Monash University, Melbourne, Victoria 3800, Australia.
⁵Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research and Department of Molecular and Translational Science, School of Clinical Science, Monash University, Clayton, Victoria 3168, Australia.
⁶Jenner Institute, University of Oxford, Oxford OX3 7FZ, UK.
⁷Institute of Infection and Immunity, Cardiff University School of Medicine,Heath Park, Cardiff CF14 4XN, UK.

↵*Corresponding author. Email: anthony.purcell{at}monash.edu (A.W.P.); nathan.croft{at}monash.edu (N.P.C.)

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Science Immunology 12 Oct 2018:
Vol. 3, Issue 28, eaar3947
DOI: 10.1126/sciimmunol.aar3947

Pouya Faridi

Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Australia.

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Chen Li

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Sri H. Ramarathinam

Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Australia.

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Julian P. Vivian

Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Australia.Australian Research Council Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, Victoria 3800, Australia.

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Patricia T. Illing

Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Australia.

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Nicole A. Mifsud

Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Australia.

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Rochelle Ayala

Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Australia.

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Jiangning Song

Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Australia.Monash Centre for Data Science, Faculty of Information Technology, Monash University, Melbourne, Victoria 3800, Australia.

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Linden J. Gearing

Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research and Department of Molecular and Translational Science, School of Clinical Science, Monash University, Clayton, Victoria 3168, Australia.

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Paul J. Hertzog

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Nicola Ternette

Jenner Institute, University of Oxford, Oxford OX3 7FZ, UK.

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Jamie Rossjohn

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Nathan P. Croft

Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Australia.

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For correspondence: anthony.purcell@monash.edu nathan.croft@monash.edu

Anthony W. Purcell

Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Australia.

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For correspondence: anthony.purcell@monash.edu nathan.croft@monash.edu

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A subset of HLA-I peptides are not genomically templated: Evidence for cis- and trans-spliced peptide ligands

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