Research ArticleTISSUE REPAIR

Emergence of immunoregulatory Ym1+Ly6Chi monocytes during recovery phase of tissue injury

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Science Immunology  05 Oct 2018:
Vol. 3, Issue 28, eaat0207
DOI: 10.1126/sciimmunol.aat0207

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Monocytes mediate repair

Different subsets of macrophages contribute to inflammation during tissue injury or resolution of inflammation and tissue repair, but the distinct subsets of macrophages that support tissue repair are not well defined. Ikeda et al. now define a role for immunoregulatory Ym1+Ly6Chi monocytes during the recovery phase of tissue injury. Bone marrow–resident precursors of Ly6Chi monocytes express Ym1 during the final stage of differentiation, and these Ym1+Ly6Chi monocytes expand in the bone marrow during late phases of inflammation. These monocytes have an immunoregulatory phenotype and are required for recovery from tissue injury in a mouse model of colitis. These findings highlight a role for bone marrow–originated Ym1+Ly6Chi monocytes in tissue repair.